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GENE:

TRIM46 (Tripartite Motif Containing 46)

News alerts, weekly reports and conference planners

24d

TRIM46 deficiency‑induced DNA damage enhances the sensitivity of cisplatin in non‑small cell lung cancer by regulating the Akt signaling pathway. (PubMed, Oncol Rep)

Furthermore, TRIM46 deficiency inhibited tumor growth and increased DDP sensitivity in vivo. In conclusion, the results of the present study demonstrated that TRIM46 contributed to DDP resistance by regulating the Akt signaling pathway and DNA damage, thereby offering new strategies for lung cancer therapy.

24 days ago

Journal

RAD51 (RAD51 Homolog A) • CASP3 (Caspase 3) • TRIM46 (Tripartite Motif Containing 46)

cisplatin

3ms

TRIM46 promotes chemoresistance of ovarian cancer via activating PHLPP2/PI3K/AKT pathway. (PubMed, Biochem Cell Biol)

Functional assays showed that TRIM46 promoted cisplatin (CDDP) chemoresistance...In summary, our study reveals that TRIM46 promoted chemoresistance via downregulating PHLPP2, leading to activating PI3K/AKT pathway. This study provides a novel potential target for ovarian cancer therapy.

3 months ago

Journal

HLPP2 (PH Domain And Leucine Rich Repeat Protein Phosphatase 2) • PHLPP2 (PH Domain And Leucine Rich Repeat Protein Phosphatase 2) • TRIM46 (Tripartite Motif Containing 46)

cisplatin

7ms

The Roles of Tripartite Motif Proteins in Urological Cancers: A Systematic Review. (PubMed, Cancers (Basel))

This review identifies TRIM proteins that are involved in urological cancers. Some of these proteins have the potential to be the therapeutic target.

7 months ago

Review • Journal

TRIM33 (Tripartite Motif Containing 33) • TRIM24 (Tripartite Motif Containing 24) • TRIM21 (Tripartite Motif Containing 21) • TRIM28 (Tripartite Motif Containing 28) • TRIM37 (Tripartite Motif Containing 37) • TRIM38 (Tripartite Motif Containing 38) • TRIM46 (Tripartite Motif Containing 46) • TRIM47 (Tripartite Motif Containing 47) • TRIM58 (Tripartite Motif Containing 58) • TRIM7 (Tripartite Motif Containing 7) • TRIM29 (Tripartite Motif Containing 29) • TRIM9 (Tripartite Motif Containing 9)

11ms

Panax notoginseng improves the sensitivity of non-small cell lung cancer to cisplatin by inhibiting Akt signaling. (PubMed, Cancer Biomark)

IGF1 reversed these effects, indicating Akt pathway involvement (p < 0.05). In vivo, Panax notoginseng and DDP significantly suppressed tumor growth and increased apoptosis in tumors, confirming enhanced chemosensitivity (p < 0.05).ConclusionPanax notoginseng can improve the sensitivity of A549/DDP cells to DDP by inhibiting the effects of TRIM46 and Akt signaling pathways on glycolysis in vivo and in vitro.

11 months ago

Journal

IGF1 (Insulin-like growth factor 1) • CASP3 (Caspase 3) • ANXA5 (Annexin A5) • SLC2A1 (Solute Carrier Family 2 Member 1) • TRIM46 (Tripartite Motif Containing 46)

cisplatin

11ms

ONECUT3 activates the TRIM46-NF-κB pathway to promote the development of pancreatic cancer. (PubMed, Biochem Biophys Res Commun)

TRIM46 overexpression also activated NF-κB signaling in PC cells. To sum up, ONECUT3 has been identified as a promising prognostic indicator in PC, and targeting this cancer-promoting pathway could offer an effective therapeutic approach to combat the PC progression.

11 months ago

Journal • IO biomarker

TRIM4 (Tripartite Motif Containing 4) • TRIM46 (Tripartite Motif Containing 46)

1year

Enhanced Expression of TRIM46 in Ovarian Cancer Cells Induced by Tumor-Associated Macrophages Promotes Invasion via the Wnt/β-Catenin Pathway. (PubMed, Cells)

Notably, pre-treatment with reparixin, a CXCR1/2 inhibitor, blocked OC-MQ-induced TRIM46 expression and cell invasion. These results suggest that CXCL8 derived from TAMs promotes human ovarian cancer cell invasion via the Wnt/β-catenin pathway by upregulating TRIM46.

1 year ago

Journal

CXCL8 (Chemokine (C-X-C motif) ligand 8) • CXCR1 (Chemokine (C-X-C motif) receptor 1) • TRIM4 (Tripartite Motif Containing 4) • TRIM46 (Tripartite Motif Containing 46)

reparixin (DF 1681Y)

over1year

Comprehensive analysis of ferroptosis-related genes indicates that TRIM46 is a novel biomarker and promotes the progression of ovarian cancer via modulating ferroptosis and Wnt signaling pathway. (PubMed, Am J Cancer Res)

TRIM46 was also associated with changes in ferroptosis-related markers and demonstrated a close connection with the Wnt signaling pathway, validated through Western blot experiments. Overall, the study provided a comprehensive understanding of the role of DEGs related to ferroptosis in OC, offering valuable insights into disease mechanisms and potential therapeutic targets.

over 1 year ago

Journal

TRIM46 (Tripartite Motif Containing 46)

over1year

Oxymatrine induces apoptosis in non-small cell lung cancer cells by downregulating TRIM46. (PubMed, Toxicon)

Meanwhile, we found that apoptosis induced by oxymatrine was inhibited by over-expressing TRIM46. Furthermore, our study indicated that the NF-κB signaling pathway was involved in apoptosis suppressed by TRIM46.We conclude that TRIM46 is the direct target of oxymatrine to induce anti-tumor apoptosis and may activate the downstream NF-κB signaling pathway.

over 1 year ago

Journal

TRIM46 (Tripartite Motif Containing 46)

almost2years

LncRNA CCAT1 knockdown suppresses tongue squamous cell carcinoma progression by inhibiting the ubiquitination of PHLPP2. (PubMed, Mol Cell Biochem)

CCAT1 mediated the ubiquitination and degradation of PHLPP2 by TRIM46, thereby promoting TSCC growth and metastasis. CCAT1/TRIM46/PHLPP2 axis regulated proliferation and invasion of TSCC cells, implying that CCAT1 would be a novel therapeutic target for TSCC patients.

almost 2 years ago

Journal

IGF2BP1 (Insulin Like Growth Factor 2 MRNA Binding Protein 1) • CCAT1 (Colon Cancer Associated Transcript 1) • HLPP2 (PH Domain And Leucine Rich Repeat Protein Phosphatase 2) • TRIM46 (Tripartite Motif Containing 46) • WTAP (WT1 Associated Protein)

almost2years

Constructing a Prognostic Model of Uterine Corpus Endometrial Carcinoma and Predicting Drug-Sensitivity Responses Using Programmed Cell Death-Related Pathways. (PubMed, J Cancer)

It was observed that UCEC patients with a high PCD score may not benefit from immunotherapy, but some chemo drugs like Bortezomib may be useful...This model accurately predicts the clinical prognosis and drug sensitivity of UCEC. The findings suggest that the PCD signature can serve as a valuable tool in assessing prognosis and guiding treatment decisions for UCEC patients.

almost 2 years ago

Journal • IO biomarker

CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • AKT2 (V-akt murine thymoma viral oncogene homolog 2) • MAPT (Microtubule Associated Protein Tau) • NOS2 (Nitric Oxide Synthase 2) • ELAPOR1 (Endosome-Lysosome Associated Apoptosis And Autophagy Regulator 1) • TRIM46 (Tripartite Motif Containing 46) • TRIM58 (Tripartite Motif Containing 58)

bortezomib

2years

Machine learning algorithm integrates bulk and single-cell transcriptome sequencing to reveal immune-related personalized therapy prediction features for pancreatic cancer. (PubMed, Aging (Albany NY))

Eventually, we identified eight therapeutic targets and one agent for IRS high patients. Our study screened out the specific regulation pattern of TIME in PC, and shed light on the precise treatment of PC.

2 years ago

Journal • IO biomarker • Machine learning

CD74 (CD74 Molecule) • SPP1 (Secreted Phosphoprotein 1) • CXCL9 (Chemokine (C-X-C motif) ligand 9) • AFF3 (AF4/FMR2 Family Member 3) • ANLN (Anillin Actin Binding Protein) • TRIM46 (Tripartite Motif Containing 46)

over2years

Cross-phenotype association analysis of gastric cancer: in-silico functional annotation based on the disease-gene network. (PubMed, Gastric Cancer)

These findings identified seven GC-associated genes exhibiting a cross-association with GFR, BUN, and UA.

over 2 years ago

Journal

MUC1 (Mucin 1) • PSCA (Prostate Stem Cell Antigen 2) • TRIM46 (Tripartite Motif Containing 46)

PSCA Expression