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TRIM29 (Tripartite Motif Containing 29)

News alerts, weekly reports and conference planners

Lactylation-drived TRIM29 induces invasive behavior and lymph node metastasis in gastric cancer via hnRNPA1-mediated Wnt/β-catenin pathway. (PubMed, Cell Death Dis)

Lactylation of TRIM29 promotes invasive behavior and lymph node metastasis in GC cells by engaging the hnRNPA1-mediated Wnt/β-catenin pathway. Targeting TRIM29 and lymphangiogenesis may be a promising therapeutic strategy for patients with advanced GC.

9 days ago

Journal

TRIM29 (Tripartite Motif Containing 29)

5-fluorouracil

Expression of TRIM29 and its association with p40 and TTF1 in lung carcinoma. (PubMed, Rev Esp Patol)

TRIM29 is a promising biomarker for NSCLC, particularly in differentiating SCC from ADC. Its strong association with p40, coupled with an inverse relationship with TTF1, enhances its diagnostic utility. Further studies are needed to explore its role in lung cancer pathogenesis and prognosis.

1 month ago

Journal

TTF1 (Transcription Termination Factor 1) • NKX2-1 (NK2 Homeobox 1) • TRIM29 (Tripartite Motif Containing 29)

3ms

RETRACTION: TRIM29 as a Novel Biomarker in Pancreatic Adenocarcinoma. (PubMed, Dis Markers)

[This retracts the article DOI: 10.1155/2014/317817.].

3 months ago

Journal

TRIM29 (Tripartite Motif Containing 29)

3ms

USP18 promotes nasopharyngeal carcinoma radioresistance via TRIM29 oligomerization and ubiquitination. (PubMed, Cell Death Differ)

Clinically, high USP18 levels are associated with worse patient prognosis. Our findings underscore the critical role of USP18 in modulating DDR signaling and radiosensitivity in NPC, suggesting that targeting the USP18-TRIM21-TRIM29 axis may represent a novel strategy to enhance the efficacy of radiotherapy for patients with NPC.

3 months ago

Journal

USP18 (Ubiquitin Specific Peptidase 18) • TRIM21 (Tripartite Motif Containing 21) • USP1 (Ubiquitin Specific Peptidase 1) • TRIM29 (Tripartite Motif Containing 29)

5ms

Cell-Free DNA Bisulfite Sequencing Reveals Epithelial-Mesenchymal Transition Signatures for Breast Cancer. (PubMed, Int J Mol Sci)

The DNA methylation and EMT changes were validated through The Cancer Genome Atlas Breast Invasive Carcinoma study, which confirmed that DMGs were associated with gene expression change and that our methylation-based EMT score reliably distinguished tumors from healthy controls. Our findings support the utilization of the NAF cfDNA cfBS methylation profile for noninvasive BrC screening and pave the way for enhanced early detection of this disease.

5 months ago

Journal

CDH1 (Cadherin 1) • COL5A2 (Collagen Type V Alpha 2 Chain) • TRIM29 (Tripartite Motif Containing 29) • WNT2 (Wnt Family Member 2)

6ms

TRIM29 promotes bladder cancer invasion by regulating the intermediate filament network and focal adhesion. (PubMed, Oncogene)

Further, we find that both K14 and the focal adhesion protein, ZYX are required for bladder cancer migration and invasion. Taken together, these results establish a role for TRIM29 in the regulation of cytoskeleton and focal adhesions during invasion and identify a pathway with therapeutic potential.

6 months ago

Journal

TP63 (Tumor protein 63) • TRIM29 (Tripartite Motif Containing 29)

6ms

Integrative bulk RNA analysis unveils immune evasion mechanisms and predictive biomarkers of osimertinib resistance in non-small cell lung cancer. (PubMed, Discov Oncol)

These findings offer novel insights into resistance mechanisms and propose actionable strategies for integrating targeted and immunotherapies to improve outcomes for NSCLC patients. Future experimental and clinical studies are essential to validate and translate these findings into therapeutic advances.

6 months ago

Journal • IO biomarker

CD8 (cluster of differentiation 8) • KRT17 (Keratin 17) • KRT14 (Keratin 14) • TP63 (Tumor protein 63) • KRT5 (Keratin 5) • KRT16 (Keratin 16) • KRT6A (Keratin 6A) • TRIM29 (Tripartite Motif Containing 29)

EGFR mutation

Tagrisso (osimertinib)

7ms

The Roles of Tripartite Motif Proteins in Urological Cancers: A Systematic Review. (PubMed, Cancers (Basel))

This review identifies TRIM proteins that are involved in urological cancers. Some of these proteins have the potential to be the therapeutic target.

7 months ago

Review • Journal

TRIM33 (Tripartite Motif Containing 33) • TRIM24 (Tripartite Motif Containing 24) • TRIM21 (Tripartite Motif Containing 21) • TRIM28 (Tripartite Motif Containing 28) • TRIM37 (Tripartite Motif Containing 37) • TRIM38 (Tripartite Motif Containing 38) • TRIM46 (Tripartite Motif Containing 46) • TRIM47 (Tripartite Motif Containing 47) • TRIM58 (Tripartite Motif Containing 58) • TRIM7 (Tripartite Motif Containing 7) • TRIM29 (Tripartite Motif Containing 29) • TRIM9 (Tripartite Motif Containing 9)

8ms

TRIM29 promotes glioblastoma progression via ubiquitinating NEFL and activating the PI3K/AKT signaling pathway. (PubMed, Cancer Genet)

This ubiquitination-dependent NEFL downregulation led to constitutive activation of the PI3K/AKT signaling pathway. Our findings uncover a novel TRIM29-NEFL-PI3K/AKT axis that drives glioblastoma malignancy, highlighting the therapeutic potential of targeting this pathway for GBM treatment.

8 months ago

Journal

NEFL (Neurofilament Light Chain) • TRIM29 (Tripartite Motif Containing 29)

9ms

TRIM29 upregulation contributes to chemoresistance in triple negative breast cancer via modulating S100P-β-catenin axis. (PubMed, Cell Commun Signal)

Indeed, higher expression of TRIM29, S100P and β-catenin associates with reduced recurrence free survival. This work proposes TRIM29 as an important node that modulates a unique gene network in chemoresistant TNBC and whose biological impact is mediated by modulation of S100P and β-catenin.

9 months ago

Journal

CTNNB1 (Catenin (cadherin-associated protein), beta 1) • CEACAM5 (CEA Cell Adhesion Molecule 5) • CDH6 (Cadherin 6) • CEACAM6 (CEA Cell Adhesion Molecule 6) • SERPINB3 (Serpin family B member 3) • SERPINB4 (Serpin Family B Member 4) • S100P (S100 calcium binding protein P) • TRIM29 (Tripartite Motif Containing 29)

9ms

TRIM29 promotes liver metastasis via enhancing hepatic colonization by stabilizing FAM83H to regulate keratin network in colorectal cancer. (PubMed, Cell Signal)

Importantly, targeting TRIM29-FAM83H-elicited keratin redistribution and PLXNB2 elevation effectively abrogated CRC liver metastasis. Our findings position TRIM29 as a central driver of liver metastasis in CRC and highlight its potential as a therapeutic target for reducing the risk of liver metastasis in patients.

9 months ago

Journal

TRIM29 (Tripartite Motif Containing 29)

10ms

A Novel Rexinoid Agonist, UAB116, Decreases Metastatic Phenotype in Hepatoblastoma by Inhibiting the Wnt/β-Catenin Pathway via Upregulation of TRIM29. (PubMed, Int J Mol Sci)

RNA sequencing identified an eight-fold increase in TRIM29, a gene known to inhibit β-catenin, in cells treated with UAB116. Administration of the LXR/RXR agonist, UAB116, reduces proliferation, stemness, and invasiveness of metastatic HB cells, potentially by upregulation of TRIM29, a known modulator of the Wnt/β-catenin pathway, providing support for further exploration of LXR/RXR agonism as a therapeutic strategy for metastatic HB.

10 months ago

Journal

TRIM29 (Tripartite Motif Containing 29)