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    GENE:

    TRIM17 (Tripartite Motif Containing 17)

    i
    Other names: TRIM17, Tripartite Motif Containing 17, RBCC, Testis RING Finger Protein, RNF16, Terf, RING-Type E3 Ubiquitin Transferase TRIM17, Tripartite Motif-Containing Protein 17, E3 Ubiquitin-Protein Ligase TRIM17, RING Finger Protein Terf, Ring Finger Protein 16, Tripartite Motif-Containing 17, RING Finger Protein 16, TERF
    Associations

    News

    Trials
    4ms
    TRIM17 promotes the progression of osteosarcoma by regulating PDK1 m6A modification-mediated AKT/mTOR pathway activation through ubiquitination of FTO. (PubMed, Cell Death Dis)
    Mechanistically, TRIM17 promotes the ubiquitination and degradation of FTO protein, enhances PDK1 mRNA stability via N6-methyladenosine (m6A) modification, and subsequently promotes phosphorylation-dependent activation of the AKT/mTOR signaling pathway, thereby driving osteosarcoma malignancy. In summary, our findings suggest that TRIM17 may serve as a potential prognostic marker and therapeutic target for osteosarcoma.
    Journal
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    FTO (Alpha-Ketoglutarate-Dependent Dioxygenase FTO) • TRIM17 (Tripartite Motif Containing 17)
    7ms
    ILF3 promotes colorectal cancer cell resistance to ferroptosis by enhancing cysteine uptake and GSH synthesis via stabilizing SLC3A2 mRNA. (PubMed, Cell Death Dis)
    This resulted in increased ILF3 levels that counteracted ferroptosis. In summary, our study underscores the oncogenic function of ILF3 in CRC and suggests that ILF3 knockdown may serve as a promising therapeutic approach for CRC.
    Journal
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    SLC3A2 (Solute Carrier Family 3 Member 2) • IL3 (Interleukin 3) • TRIM17 (Tripartite Motif Containing 17)
    over2years
    The E3 ubiquitin ligase TRIM17 promotes gastric cancer survival and progression via controlling BAX stability and antagonizing apoptosis. (PubMed, Cell Death Differ)
    Moreover, TRIM17 and BAX expression levels are inversely correlated in human GC specimens. Our data thus suggest TRIM17 contributes to gastric cancer survival through regulating BAX protein stability and antagonizing apoptosis, which provides a promising therapeutic target for GC treatment and a biomarker for prognosis.
    Journal
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    BAX (BCL2-associated X protein) • TRIM17 (Tripartite Motif Containing 17)
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    BAX expression
    over2years
    Comprehensive analysis of the prognostic and immunological signature of eight Tripartitemotif (TRIM) family molecules in human gliomas. (PubMed, Aging (Albany NY))
    In general, the results indicate that TRIM5/17/21/22/24/28/34/47 might exert a crucial influence on gliomas tumorigenesis and might be putative prognostic markers and therapeutic targets for glioma patients.
    Journal • Tumor mutational burden
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    TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • TRIM17 (Tripartite Motif Containing 17) • TRIM5 (Tripartite Motif Containing 5)
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    6-gene signature