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    GENE:

    TREX2 (Three Prime Repair Exonuclease 2)

    i
    Other names: TREX2, Three Prime Repair Exonuclease 2, 3’-5’ Exonuclease TREX2 Long Form, 3’-5’ Exonuclease TREX2
    Associations

    News

    Trials
    over2years
    NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance. (PubMed, Cell Metab)
    Strikingly, genetic deletion of the glucose/NSUN2/TREX2 axis suppresses tumorigenesis and overcomes anti-PD-L1 immunotherapy resistance in those cold tumors through cGAS/STING activation to facilitate apoptosis and CD8 T cell infiltration. Our study identifies NSUN2 as a direct glucose sensor whose activation by glucose drives tumorigenesis and immunotherapy resistance by maintaining TREX2 expression for cGAS/STING inactivation.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    CD8 (cluster of differentiation 8) • STING (stimulator of interferon response cGAMP interactor 1) • CGAS (Cyclic GMP-AMP Synthase) • TREX2 (Three Prime Repair Exonuclease 2)