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    GENE:

    TRAK2 (Trafficking Kinesin Protein 2)

    i
    Other names: TRAK2, Trafficking Kinesin Protein 2, KIAA0549, ALS2CR3, CALS-C, GRIF-1, OIP98, MILT2, Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 3 Protein, Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 3, O-Linked N-Acetylglucosamine Transferase Interacting Protein 98, Gamma-Aminobutyric Acid(A) Receptor-Interacting Factor, Trafficking Protein, Kinesin Binding 2, Trafficking Kinesin-Binding Protein 2, Milton Homolog 2 (Drosophila), Milton Homolog 2, GRIF1
    Associations

    News

    Trials
    9ms
    CircSLC22A3 inhibits the invasion and metastasis of ESCC via the miR-19b-3p/TRAK2 axis and by reducing the stability of m6A-modified ACSBG1 mRNA. (PubMed, BMC Cancer)
    The present study identified circSLC22A3 as a new tumor suppressor that inhibited ESCC progression through both the circSLC22A3/ miR-19b-3p/ TRAK2 and circSLC22A3/ IGF2BP1/ ACSBG1 axes.
    Journal
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    IGF2BP1 (Insulin Like Growth Factor 2 MRNA Binding Protein 1) • MIR19B1 (MicroRNA 19b-1) • SLC22A3 (Solute Carrier Family 22 Member 3) • TRAK2 (Trafficking Kinesin Protein 2)
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    dactinomycin
    12ms
    Clinical implications and molecular mechanism of long noncoding RNA LINC00518 and protein-coding genes in skin cutaneous melanoma by genome‑wide investigation. (PubMed, Arch Dermatol Res)
    RASSF3, CABLES1, KAZN, EFCAB5 and MITF had prognostic significance. This study provided novel biomarkers for SKCM.
    Journal
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    PPL (Periplakin) • MITF (Melanocyte Inducing Transcription Factor) • EPM2A (EPM2A Glucan Phosphatase) • LINC00518 (Long Intergenic Non-Protein Coding RNA 518) • TRAK2 (Trafficking Kinesin Protein 2)
    almost3years
    Identifying mRNAs Residing in Myelinating Oligodendrocyte Processes as a Basis for Understanding Internode Autonomy. (PubMed, Life (Basel))
    Complementary in situ hybridization (ISH) is recommended to confirm residences of mRNAs in MSAS. As both proteins and lipids are synthesized in MSAS, understanding myelination should not only include efforts to identify proteins synthesized in MSAS, but also the lipids.
    Journal
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    TRAK2 (Trafficking Kinesin Protein 2)
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    TP53 expression
    almost3years
    Gamma-Aminobutyric Acid Type A Receptor Subunit Pi is a potential chemoresistance regulator in colorectal cancer. (PubMed, Mol Biol Rep)
    We identify GABRP as a promising drug target to mediate oxaliplatin or 5-FU resistance in CRC. It provided the theoretical basis and potential clinical value for CRC patients.
    Journal
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    GABARAP (GABA Type A Receptor-Associated Protein) • ANKRD66 (Ankyrin Repeat Domain 66) • CLINT1 (Clathrin Interactor 1) • GABARAPL1 (GABA Type A Receptor Associated Protein Like 1) • GABARAPL2 (GABA Type A Receptor Associated Protein Like 2) • GABRP (Gamma-Aminobutyric Acid Type A Receptor Subunit Pi) • TRAK2 (Trafficking Kinesin Protein 2)
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    5-fluorouracil • oxaliplatin