TRAF1 (TNF Receptor Associated Factor 1)

Collectively, our findings highlight UBE2B as a critical modulator of GC progression and a potential target for therapeutic intervention. Implications: This study characterizes the UBE2B-BIRC2-TRAF1 axis as a driver of NF-κB hyperactivation, identifying UBE2B as a prognostic biomarker and a potential therapeutic target for disrupting this oncogenic feedback loop in gastric cancer.

Our data highlights mutational variation across demographic cohorts. These patterns are vital to future studies into identifying diagnostic markers or therapeutic targets.

HVEM enhances CAR T cell efficacy against solid tumors by robustly activating TNF signaling through TRAF recruitment, particularly via the AVEE motif. These findings highlight HVEM as a promising co-stimulatory domain for improving CAR T cell therapy in solid tumors, with implications for metabolic reprogramming and sustained antitumor activity.

Butein effectively suppresses cSCC growth by directly binding to and inhibiting key proteins in the TWEAK-FN14 signaling pathway, thereby coordinately modulating the downstream inflammatory microenvironment. This study provides mechanistic insights and experimental evidence supporting Butein as a potential therapeutic candidate for cSCC.

Pediatric ALK+ ALCL with non-NPM1-ALK fusions exhibits diverse clinical features and outcomes. TPM3-ALK fusions might correlate with a more favorable course, while other variants may face a potentially higher relapse risk. ALK inhibitors showed promising efficacy in the salvage setting. These preliminary findings highlight the need for larger prospective studies to validate mutation-specific risk stratification and therapeutic strategies.

BA and Qe, particularly in combination, protect neuronal cells from PQ-induced oxidative and mitochondrial damage by restoring redox balance, stabilizing mitochondria, regulating Ca²⁺ homeostasis and modulating apoptosis and attenuating irritation in the in ovo model. These results suggest that BA and Qe may be promising complementary therapeutics to attenuate neurotoxicity caused by environmental toxins.

In a monosodium urate crystal-induced arthritis model, TRAF1V196A mice show reduced joint inflammation, decreased synovial immune cell infiltration, and attenuated disease severity. These findings establish the TRAF1/cIAP2 axis as a key regulator of inflammasome activation and a potential therapeutic target for inflammasome-driven diseases such as gout.

Taken together, this study establishes that the CD40-agonist greatly potentiates the efficacy of IRE-ablation for metastatic melanoma by promoting unexpected CD8+CD103+ cDC1 and CD103+TCF1+ TRM cell responses and suggests the importance of targeting CD40-signaling to improve the efficacy of cancer IRE-ablation therapy.

Connective tissue diseases require early diagnosis, interdisciplinary strategy and integration of pharmacological and non-drug methods. Physical treatment methods demonstrate proven effectiveness in the context of a comprehensive approach to therapy. Physical therapy with a high level of evidence (I, A) improves the function of joints and lungs, as well as contributes to the reduction of fibrosis severity. UVA-1 phototherapy is a method of choice for improving the skin elasticity in scleroderma and skin forms of the connective tissue diseases by inhibiting TGF-β and collagen synthesis. Ultrasound therapy in combination with hyaluronidase, high-intensity dye laser therapy are indicated for reduction of the vascular disorders in tissues. Cryotherapy (whole-body and local), electrophoresis with corticosteroids have a local anti-inflammatory effect, complement the range of non-drug interventions, improving the quality of life of patients, but require individualization of parameters. Personalization of treatment based on genetic markers, as well as the introduction of innovative methods (targeted therapy) can reduce the risk of complications, but problems of resistance and iatrogenic effects remain. Further research should be aimed at the study of the role of microbiome and development of pathogenetically substantiated drugs.

This work reports the infection-responsive expression landscape of traf genes in E. fuscoguttatus, highlighting Efutrafs as important regulators of teleost host defense against bacterial pathogens. These findings establish a critical foundation for understanding grouper immunology.

Furthermore, the lipopolysaccharide (LPS) challenge induced significant temporal modulation of EtTRAF expression patterns. Collectively, our systematic investigation of TRAFs in E. tetradactylum provides critical insights into their putative roles in innate immune defense against pathogens and establishes a framework for future functional studies on TRAF-mediated signaling in teleost fishes.

[This retracts the article DOI: 10.3892/ol.2018.7914.].