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    BIOMARKER:

    TRAF1 overexpression

    i
    Other names: TRAF1, TNF Receptor Associated Factor 1, EBI6, TNF Receptor-Associated Factor 1, Epstein-Barr Virus-Induced Protein 6, Epstein-Bar Virus-Induced Protein 6, MGC:10353
    Entrez ID:
    7185
    over3years
    N-methyladenosine-modified TRAF1 promotes sunitinib resistance by regulating apoptosis and angiogenesis in a METTL14-dependent manner in renal cell carcinoma. (PubMed, Mol Cancer)
    Overexpression of TRAF1 promotes sunitinib resistance by modulating apoptotic and angiogenic pathways in a METTL14-dependent manner. Targeting TRAF1 and its pathways may be a novel pharmaceutical intervention for sunitinib-treated patients.
    Journal
    |
    TNFA (Tumor Necrosis Factor-Alpha) • TRAF1 (TNF Receptor Associated Factor 1) • METTL14 (Methyltransferase 14)
    |
    TRAF1 overexpression
    |
    sunitinib