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BIOMARKER:

TP73 expression

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Other names: TP73, Tumor Protein P73, P73, P53-Like Transcription Factor 3, P53-Related Protein 3
Entrez ID:
Related biomarkers:
Associations
Trials
1year
Construction and identification of lncRNA/circRNA coregulated ceRNA networks in gemcitabine-resistant bladder carcinoma. (PubMed, Carcinogenesis)
Modulation of ceRNA network components using ablation and overexpression approaches contributed to gemcitabine resistance in bladder cancer cells. These results elucidate mechanisms by which lncRNAs and circRNAs coregulate the development of bladder cancer cell resistance to gemcitabine, thus laying the foundation for future research to identify biomarkers and disease targets.
Journal
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MIR324 (MicroRNA 324) • ST6GAL1 (ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 1) • TP73 (Tumor Protein P73) • MIR193A (MicroRNA 193a)
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TP73 expression
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gemcitabine
over1year
Downregulation of long noncoding RNA TP73-AS1 expression confers resistance to temozolomide in human glioblastoma cells. (PubMed, Nucleosides Nucleotides Nucleic Acids)
Additionally, TP73-AS1 knockdown in parental U87MG cells decreased their sensitivity to TMZ. Overall, these findings suggest that TP73-AS1 functions as a regulator of TMZ sensitivity in GBM cells.
Journal
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TP73 (Tumor Protein P73)
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TP73 expression
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temozolomide
almost2years
LncRNA TP73-AS1 enhances the malignant properties of colorectal cancer by increasing SPP-1 expression through miRNA-539-5p sponging. (PubMed, Pathol Res Pract)
In a word, we found that TP73-AS1 enhances the malignant properties of colorectal cancer by increasing SPP-1 expression through miRNA-539-5p sponging. And our study provides a potential therapeutic target of CC.
Journal
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TP73 (Tumor Protein P73)
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TP73 expression
over2years
Long non-coding RNA tumor protein 73 antisense RNA 1 influences an interaction between lysine demethylase 5A and promoter of tumor protein 73 to enhance the malignancy of colorectal cancer. (PubMed, Hum Cell)
Interestingly, the H3K4me3 level on the TP73 promoter was reduced, but was elevated by TP73-AS1 knockdown in CRC cells. In conclusion, these results suggest a novel epigenetic role of TP73-AS1 on histone demethylation that influences TP73 transcription, and shed light on malignancy in CRC.
Journal
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KDM5A (Lysine Demethylase 5A) • TP73 (Tumor Protein P73)
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TP73 expression
over2years
Circulating TP73-AS1 and CRNDE serve as diagnostic and prognostic biomarkers for non-small cell lung cancer. (PubMed, Cancer Med)
Circulating TP73-AS1 and CRNDE could be potential biomarkers for the diagnosis and prognostic prediction of NSCLC.
Journal
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CEACAM5 (CEA Cell Adhesion Molecule 5) • KRT19 (Keratin 19) • TP73 (Tumor Protein P73)
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TP73 expression
over2years
The Robust Tumoricidal Effects of Combined BET/HDAC Inhibition in CTCL Can Be Reproduced by ΔNp73 Depletion. (PubMed, J Invest Dermatol)
CTCL skin lesions expressed both TAp73 and ΔNp73 isoforms in situ. In aggregate, these findings implicate TAp73/ΔNp73 balance as a major factor governing CTCL survival, show that expression of p73 isoforms can be altered by molecular biological and pharmaceutical means, demonstrate that p73 isoforms are expressed across the entire CTCL clinical spectrum, and identify the p73 pathway as a potential target for therapeutics.
Journal • IO biomarker
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BCL2 (B-cell CLL/lymphoma 2) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • BIRC5 (Baculoviral IAP repeat containing 5) • CD70 (CD70 Molecule) • CD40 (CD40 Molecule) • PRKCA (Protein Kinase C Alpha) • TP73 (Tumor Protein P73)
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TP73 expression
over2years
Identification of the Potential Correlation between Tumor Protein 73 and Head and Neck Squamous Cell Carcinoma. (PubMed, Dis Markers)
Integrative bioinformatics and statistical analyses displayed that TP73 might serve as a novel marker for the diagnosis and prognosis of HNSC. TP73 modulates immune cells in the tumor microenvironment of HNSC patients, thereby bearing significance for HNSC immunotherapy.
Journal • IO biomarker
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TP73 (Tumor Protein P73)
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TP73 expression
over3years
Journal
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TP73 (Tumor Protein P73)
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TP73 expression
over3years
TP73-AS1 is induced by YY1 during TMZ treatment and highly expressed in the aging brain. (PubMed, Aging (Albany NY))
TP73-AS1 is a long noncoding RNA (lncRNA) over expressed in GBM tumors shown to promote resistance to the chemotherapeutic temozolomide (TMZ), and tumor aggressiveness...Together, our data positions YY1 as an important TP73-AS1 regulator, demonstrating that TP73-AS1 is expressed in the natural and pathological aging brain, including during neurodegeneration and cancer. Our findings advance our understanding of TP73-AS1 expression, bringing forth a new link between TMZ resistance and aging, both of which contribute to GBM morbidity.
Journal
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TP73 (Tumor Protein P73)
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TP73 expression
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temozolomide
over3years
Integrative analysis of TP73 profile prognostic significance in WHO grade II/III glioma. (PubMed, Cancer Med)
Finally, TP73 expression of 53 glioma specimens was measured by qRT-PCR, which was consistent with the previous analytical result, and TP73 high-expression subgroup suffered worse PFS than TP73 low-expression subgroup. In summary, our funding supports that TP73 gene can perform as a reliable biomarker to evaluate the survival outcome of patients diagnosed with WHO grade II/III glioma.
Journal
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TP73 (Tumor Protein P73)
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TP73 expression
over3years
Long non-coding RNA TP73-AS1 promotes pancreatic cancer growth and metastasis through miRNA-128-3p/GOLM1 axis. (PubMed, World J Gastroenterol)
Our results demonstrated that TP73-AS1 promotes PC progression by regulating the miR-128-3p/GOLM1 axis, which might provide a potential treatment strategy for patients with PC.
Journal
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TP73 (Tumor Protein P73) • MIR128 (MicroRNA 128)
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TP73 expression
almost4years
Long noncoding RNA CASC7 inhibits the proliferation and migration of papillary thyroid cancer cells by inhibiting miR-34a-5p. (PubMed, J Physiol Sci)
Moreover, miR-34a-5p mimic transfection could abate the CASC7-regulated PTC cell proliferation, migration, and apoptosis. Collectively, CASC7 inhibited the proliferation and migration of PTC cells by sponging miR-34a-5p to upregulate TP73 expression.
Journal
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MIR34A (MicroRNA 34a-5p) • TP73 (Tumor Protein P73)
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miR-34a expression • TP73 expression
almost4years
[VIRTUAL] TP73 expression may be influenced by DNA methylation in human tumorigenesis (AACR 2021)
Our observations demonstrate that a positive correlation in tumorigenesis exists between TP73 expression and DNA methylation in promoter regions of TP73. These findings suggest that TP73’s role in carcinogenesis may prove to be pivotal for the development of future diagnostic and therapeutic applications.
Epigenetic controller
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TP53 (Tumor protein P53) • TP73 (Tumor Protein P73)
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TP73 expression