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    GENE:

    TP53INP2 (Tumor Protein P53 Inducible Nuclear Protein 2)

    i
    Other names: TP53INP2, Tumor Protein P53 Inducible Nuclear Protein 2, PINH, DOR, DJ1181N3.1, C20orf110, Tumor Protein P53-Inducible Nuclear Protein 2, P53-Inducible Protein U, DKFZp434B2411, DKFZp434O0827, FLJ21759, FLJ23500, PIG-U, Chromosome 20 Open Reading Frame 110, Diabetes And Obesity-Regulated Gene, Diabetes And Obesity Regulated, Diabetes And Obesity-Regulated, PIGU
    Associations

    News

    Trials
    10d
    Mammalian lipophagy: process and function. (PubMed, Autophagy)
    In contrast, this review focuses specifically on mammalian lipophagy by synthesizing the latest mechanistic insights into receptor-mediated recognition, transcriptional regulation, and signaling integration. We also outline unresolved questions and conceptual gaps - such as how lipophagy is selectively activated, how it coordinates with lipolysis, and whether distinct receptor codes exist in tissue- and disease-specific contexts - that remain unanswered in the current literature.
    Review • Journal
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    SQSTM1 (Sequestosome 1) • TFE3 (Transcription Factor Binding To IGHM Enhancer 3) • PPARG (Peroxisome Proliferator Activated Receptor Gamma) • TFEB (Transcription Factor EB 2) • PPARA (Peroxisome Proliferator Activated Receptor Alpha) • TP53INP2 (Tumor Protein P53 Inducible Nuclear Protein 2)
    2ms
    Fatty acid metabolism-related signature suggests an oncogenic role of FASN in cervical cancer. (PubMed, Transl Cancer Res)
    This study clarified a specific signature associated with fatty acid metabolism, specifically FASN, which is connected to both the initiation and progression of CESC. Furthermore, FASN may serve as a prognostic marker for individuals diagnosed with CESC, thus providing fresh insights for the formulation of clinical treatment strategies.
    Journal
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    FAS (Fas cell surface death receptor) • FASN (Fatty acid synthase) • HMGCS1 (3-Hydroxy-3-Methylglutaryl-CoA Synthase 1) • IL4I1 (Interleukin 4 Induced 1) • TP53INP2 (Tumor Protein P53 Inducible Nuclear Protein 2)
    2ms
    A C-terminal cytoplasmic retention motif and nuclear localization signal regulates nuclear import of TP53INP2/DOR. (PubMed, J Cell Sci)
    Finally, starvation enhances TP53INP2 translation via the m6A demethylase FTO, without altering mRNA stability. These findings uncover coordinated regulation of TP53INP2 localization and turnover by cellular stress.
    Journal
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    TP53 (Tumor protein P53) • ATG5 (Autophagy Related 5) • FTO (Alpha-Ketoglutarate-Dependent Dioxygenase FTO) • TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1) • TP53INP2 (Tumor Protein P53 Inducible Nuclear Protein 2)
    3ms
    The anti-cancer role of tumor protein p53-inducible nuclear protein 2/nuclear factor-kB/nuclear factor erythroid 2-related factor 2/heme oxygenase-1 pathway in spinal cord glioma. (PubMed, Cytojournal)
    The silenced TP53INP2 hampered the activation of NF-kB and promoted the activation of the Nrf2/HO-1 pathway. This work highlights the therapeutic potential of TP53INP2/NF-kB/Nrf2/HO-1 axis in SCG.
    Journal
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    TP53 (Tumor protein P53) • HMOX1 (Heme Oxygenase 1) • TP53INP2 (Tumor Protein P53 Inducible Nuclear Protein 2)
    7ms
    Exploring of bladder cancer immune-related genes and potential therapeutic targets based on transcriptomic data and Mendelian randomization analysis. (PubMed, Front Immunol)
    This study identified six immunoregulatory genes that were significantly negatively associated with bladder cancer risk. These genes may serve not only as potential biomarkers for bladder cancer immunity but also contribute to a deeper understanding of the molecular mechanisms of bladder cancer.
    Journal
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    IL1R1 (Interleukin 1 receptor, type I) • CYP27A1 (Cytochrome P450 Family 27 Subfamily A Member 1) • TP53INP2 (Tumor Protein P53 Inducible Nuclear Protein 2)
    9ms
    Patient-specific gene co-expression networks reveal novel subtypes and predictive biomarkers in lung adenocarcinoma. (PubMed, NPJ Syst Biol Appl)
    Supervised analysis, employing regularized Cox regression, identified 12 genes (CHRDL2, SPP2, VAC14, IRF5, GUCY1B1, NCS1, RRM2B, EIF5A2, CCDC62, CTCFL, XG, and TP53INP2) whose weighted degree in SSNs is predictive of patient survival in LUAD. These findings suggest that topological features of SSNs offer valuable insights into the context-specific nature of LUAD malignancy, highlighting the potential of SSN-based approaches for further research.
    Journal
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    EIF5A2 (Eukaryotic Translation Initiation Factor 5A2) • IRF5 (Interferon Regulatory Factor 5) • TP53INP2 (Tumor Protein P53 Inducible Nuclear Protein 2)
    10ms
    RETRACTION: Pachymic Acid Activates TP53INP2/TRAF6/Caspase-8 Pathway to Promote Apoptosis in Renal Cell Carcinoma Cells. (PubMed, Environ Toxicol)
    Therefore, the article must be retracted. Deyu Zuo disagrees with this decision on behalf of the authors.
    Journal
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    CASP8 (Caspase 8) • TP53INP2 (Tumor Protein P53 Inducible Nuclear Protein 2) • TRAF6 (TNF Receptor Associated Factor 6)
    11ms
    TP53INP2 promotes mitophagic degradation of YAP to impede dedifferentiated liposarcoma development. (PubMed, Oncogene)
    The WW domain in YAP and the PPTY motif in VDAC1 are required for their interaction. Taken together, these data demonstrate that TP53INP2 represses the malignant progression of DDLPS by inactivating YAP via a mitophagy-dependent mechanism and that TP53INP2 may constitute a novel prognostic biomarker for advanced DDLPS.
    Journal
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    TP53 (Tumor protein P53) • TP53INP2 (Tumor Protein P53 Inducible Nuclear Protein 2) • VDAC1 (Voltage Dependent Anion Channel 1)
    1year
    HIF-3α Facilitates the Proliferation and Migration in Pancreatic Cancer by Inhibiting Autophagy Through Downregulating TP53INP2. (PubMed, Cell Biochem Biophys)
    Furthermore, HIF-3α overexpression facilitated the in vivo growth of PANC-1 cells, accompanied by the autophagy inhibition in tumor tissues, which were remarkably abolished by TP53INP2 overexpressing. Collectively, HIF-3α facilitated the proliferation and migration in pancreatic cancer by inhibiting autophagy through downregulating TP53INP2.
    Journal
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    ATG7 (Autophagy Related 7) • BECN1 (Beclin 1) • TP53INP2 (Tumor Protein P53 Inducible Nuclear Protein 2)
    over1year
    DOR activation in mature oligodendrocytes regulates α-ketoglutarate metabolism leading to enhanced remyelination in aged mice. (PubMed, Nat Neurosci)
    Supplementation with α-ketoglutarate restores oligodendrocyte-maturation defects in Dor-deficient adult mice and improves remyelination after lysolecithin-induced demyelination and cognitive function in 17-month-old wild-type mice. Our data suggest that activation of α-ketoglutarate metabolism in mature oligodendrocytes can promote myelin production during demyelination and aging.
    Preclinical • Journal
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    TP53 (Tumor protein P53) • SOX10 (SRY-Box 10) • TP53INP2 (Tumor Protein P53 Inducible Nuclear Protein 2)
    over1year
    Cytoplasmic TP53INP2 acts as an apoptosis partner in TRAIL treatment: the synergistic effect of TRAIL with venetoclax in TP53INP2-positive acute myeloid leukemia. (PubMed, J Exp Clin Cancer Res)
    Our findings revealed that TP53INP2 is a predictor of responsiveness to TRAIL treatment and supported a potentially individualized therapeutic strategy for TP53INP2-positive AML patients.
    Journal • IO biomarker
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    NPM1 (Nucleophosmin 1) • CASP8 (Caspase 8) • TP53INP2 (Tumor Protein P53 Inducible Nuclear Protein 2) • TRAF6 (TNF Receptor Associated Factor 6)
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    Venclexta (venetoclax)
    over1year
    Comprehensive analysis of autophagy associated genes and immune infiltrates in cervical cancer. (PubMed, Iran J Basic Med Sci)
    Furthermore, MAPK3 was positively correlated with LGALS9, and negatively correlated with CTLA4 and CD40. Our results show that MAPK3 can be used as a new prognostic biomarker to predict the prognosis of patients with CC.
    Journal • IO biomarker
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    HER-2 (Human epidermal growth factor receptor 2) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • BIRC5 (Baculoviral IAP repeat containing 5) • CCL2 (Chemokine (C-C motif) ligand 2) • CD40 (CD40 Molecule) • DNAJB1 (DnaJ Heat Shock Protein Family (Hsp40) Member B1) • IKBKE (Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon) • TNFSF10 (TNF Superfamily Member 10) • HSPB8 (Heat Shock Protein Family B (Small) Member 8) • ITGB4 (Integrin Subunit Beta 4) • LGALS9 (Galectin 9) • MAPK3 (Mitogen-Activated Protein Kinase 3) • PTK6 (Protein Tyrosine Kinase 6) • SPHK1 (Sphingosine Kinase 1) • TP53INP2 (Tumor Protein P53 Inducible Nuclear Protein 2)