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    BIOMARKER:

    TP53BP1 mutation

    i
    Other names: TP53BP1, Tumor Protein P53 Binding Protein 1, 53BP1, TP53-Binding Protein 1, P53-Binding Protein 1, TDRD30, P53BP1, P202, Tumor Suppressor P53-Binding Protein 1, Tumor Protein P53-Binding Protein 1, Tumor Protein 53-Binding Protein 1
    Entrez ID:
    7158
    over2years
    Plasma Circulating Tumor DNA (ctDNA) as an Alternative to Tissue DNA for Genotyping of DLBCL: Results from the POLARIX Study (ASH 2023)
    Introduction: In the POLARIX study (NCT03274492), polatuzumab vedotin in combination with rituximab plus cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) demonstrated prolonged progression-free survival (PFS) versus rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in patients with previously untreated diffuse large B-cell lymphoma (DLBCL; Tilly et al. Our analyses demonstrated that the mutation landscape of ctDNA in DLBCL characterized by the AVENIO ctDNA NHL assay resembles that of tumor tissue determined by WES. Patients with molecular subtypes defined by WES or ctDNA had similar PFS outcomes. Overall, these findings support the use of plasma ctDNA as an alternative to tumor tissue for the genotyping of DLBCL.
    IO biomarker • Circulating tumor DNA
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    TP53 (Tumor protein P53) • BCL2 (B-cell CLL/lymphoma 2) • NOTCH1 (Notch 1) • BCL6 (B-cell CLL/lymphoma 6) • TET2 (Tet Methylcytosine Dioxygenase 2) • KMT2D (Lysine Methyltransferase 2D) • CD79B (CD79b Molecule) • NOTCH2 (Notch 2) • TNFAIP3 (TNF Alpha Induced Protein 3) • DCHS1 (Dachsous Cadherin-Related 1) • TP53BP1 (Tumor Protein P53 Binding Protein 1)
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    TP53 mutation • NOTCH1 mutation • TET2 mutation • KMT2D mutation • EZH2 mutation • MYD88 L265P • CD79B mutation • BCL6 rearrangement • CD79B mutation • NOTCH2 mutation • BCL2 rearrangement • BCL6 translocation • MYD88 L265P + CD79B mutation • TP53BP1 mutation • BCL2 translocation
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    Rituxan (rituximab) • doxorubicin hydrochloride • cyclophosphamide • vincristine • prednisone • Polivy (polatuzumab vedotin-piiq)