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    BIOMARKER:

    TP53 deletion + RB1 deletion + CTSK expression

    i
    Other names: TP53, Tumor Protein P53, Cellular Tumor Antigen P53, Phosphoprotein P53, Tumor Protein P53, Antigen NY-CO-13, Transformation-Related Protein 53, Mutant Tumor Protein 53, P53 Tumor Suppressor, Tumor Suppressor P53, Tumor Protein 53, BMFS5, TRP53, BCC7, LFS1 ,Cathepsin K, Cathepsin O2, Cathepsin O, Cathepsin X, CTSO2, CTSO, PKND, Cathepsin K (Pycnodysostosis), Cathepsin O1, CTS02, CTSO1, PYCD, CTSK, RB1, RB Transcriptional Corepressor 1, Protein Phosphatase 1 Regulatory Subunit 130, Prepro-Retinoblastoma-Associated Protein, Retinoblastoma-Associated Protein, Retinoblastoma 1, P110-RB1, P105-Rb, Pp110, PRb, Exon 17 Tumor GOS561 Substitution Mutation Causes Premature Stop, GOS563 Exon 17 Substitution Mutation Causes Premature Stop, Retinoblastoma Suspectibility Protein, Osteosarcoma, PPP1R130, OSRC, RB, Rb, pRb,
    Entrez ID:
    7157; 5925; 1513
    Related biomarkers:
    Expression
    Mutation
    CNA
    Fusion
    Others
    over2years
    Deletion of Trp53 and Rb1 in Ctsk-expressing cells drives osteosarcoma progression by activating glucose metabolism and YAP signaling. (PubMed, MedComm (2020))
    Ablation of YAP signaling inhibited energy metabolism and delayed osteosarcoma progression in Ctsk-Cre;Trp53/Rb1 mice. Collectively, these findings provide proof of principle that inhibition of YAP activity may be a potential strategy for osteosarcoma treatment.
    Journal
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    TP53 (Tumor protein P53) • RB1 (RB Transcriptional Corepressor 1) • CTSK (Cathepsin K)
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    TP53 mutation • RB1 deletion • TP53 deletion + RB1 deletion + CTSK expression