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    DRUG:

    Tozaride (Rhenium (Re) 188 P2045)

    i
    Other names: rhenium-188 P2045, Rhenium (Re) 188 P2045, rhenium-188 P 2045, BAY-865284, P2045, Re-188 P 2045, Rh-188 P2045
    Associations

    News

    Trials
    Company:
    Andarix
    Drug class:
    Ionizing radiation emitter, SSTR2 inhibitor
    Related drugs:
    Associations

    News

    Trials
    5ms
    Neoadjuvant sintilimab plus chemotherapy in EGFR-mutant NSCLC: Phase 2 trial interim results (NEOTIDE/CTONG2104). (PubMed, Cell Rep Med)
    Here, we report interim results of a Simon's two-stage design, phase 2 trial using neoadjuvant sintilimab with carboplatin and nab-paclitaxel in resectable EGFR-mutant NSCLC. Informed circulating tumor DNA (ctDNA) detection in EGFR-mutant NSCLC could help identify patients nonresponsive to neoadjuvant immunochemotherapy. These findings provide supportive data for the utilization of neoadjuvant immunochemotherapy and insight into immune resistance in EGFR-mutant NSCLC.
    P2 data • Journal • IO biomarker
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    EGFR (Epidermal growth factor receptor) • CXCL13 (Chemokine (C-X-C motif) ligand 13) • CCR8 (C-C Motif Chemokine Receptor 8)
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    carboplatin • Tyvyt (sintilimab) • albumin-bound paclitaxel • Tozaride (Rhenium (Re) 188 P2045)