Tongue Carcinoma

This interplay observed between cancer cells, neurons, and glial cells suggests a potential mechanism through which tumor-associated nerves might influence cancer stemness via metabolic reprogramming. This highlights a possible direction for anticancer therapy that warrants further investigation.

The clinical manifestations and pathological examination of the three cases were consistent with the characteristics of highly differentiated squamous cell carcinoma. Additionally, immunohistochemical analysis revealed positive expression of p63, CK5/6, p40, CK19, CK7, and CK20. In three cases, the results of human papillomavirus were negative. This study provides an important reference for the diagnosis of TSCC in rhesus monkeys.

The major conclusion of this study is that overall LVD is an indicator of aggressiveness of TSCC and a negative prognostic factor strongly associated with nodal metastasis. LVD assessment can improve risk stratification and lead to personalized treatment approaches in TSCC management.

MMP9, which originates from activated satellite glial cells in the TG, post-SCC inoculation, contributes to tongue-cancer-associated pain.

We conclude that adipocytes increase the proliferation of cancer cells and enhance their motility without direct cell contact. The protumourigenic effect of adipocytes is likely mediated by secreted cytokines, such as IL-6, and transported via EVs.

Critically, pharmacological inhibition of MTHFD2 (e.g., DS18561882) blocks FOXO1 degradation, establishing the MTHFD2-FOXO1 axis as a promising therapeutic target for TSCC through its novel metabolic-epigenetic regulatory mechanism. Implications: This study identifies the MTHFD2-FOXO1 axis as a druggable metabolic-epigenetic pathway in TSCC, providing both a prognostic marker and a therapeutic target.

Vitamin D represents an efficient anticancer adjuvant that permits a novel therapeutic strategy for cancer patients.

This case highlights the diagnostic challenges of differentiating LLTs from spindle cell lipomas (SCLs), particularly in the context of pRB deficiency and RB1 deletion. This case exemplifies the molecular heterogeneity of neoplasms with lipoblastoma-like features.

Differential expression of CHRNA3, CHRNA5, and CHRNA7 indicates different EMT states in OSCC/HNC, influencing proliferation, differentiation, cell adhesion, immune reactions, and treatment efficacy, and warrants further experimental validation.

P=N/A, N=600, Recruiting, Ohio State University Comprehensive Cancer Center | Trial completion date: Sep 2025 --> Dec 2025 | Trial primary completion date: Sep 2025 --> Dec 2025

P2/3, N=686, Recruiting, NRG Oncology | Suspended --> Recruiting

A tissue microarray (TMA) stained with an antibody directed against the BEND2 protein showed no significant staining in any other salivary tumor type. The constellation of findings in this cohort is highly suggestive of a specific entity, and we propose the appellation "Fenestrating Adenocarcinoma (FAC)" of the salivary gland.