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    BIOMARKER:

    TNFRSF1B overexpression

    i
    Other names: TNFRSF1B, Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor 2, Tumor necrosis factor receptor type II, p80 TNF-alpha receptor, p75, CD120b, Etanercept, TNFBR, TNFR2, TNFR80, TNF-R75
    2years
    TNFR2 blockade of regulatory T cells unleashes an antitumor immune response after hematopoietic stem-cell transplantation. (PubMed, J Immunother Cancer)
    These results highlight TNFR2 as a new target molecule for the development of immunotherapies to treat blood malignancy relapse, used either directly in grafted patients or to enhance donor lymphocyte infusion strategies. More widely, they open the door for new perspectives to amplify antitumor responses against solid cancers by directly targeting Tregs through their TNFR2 expression.
    Journal • IO biomarker
    |
    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule)
    |
    TNFRSF1B overexpression
    2years
    TNFRSF11B Suppresses Memory CD4+ T Cell Infiltration in the Colon Cancer Microenvironment: A Multiomics Integrative Analysis. (PubMed, Front Immunol)
    TNFRSF11B was closely related to lymph node invasion and pathogenic E. coli. infection, which may negatively affect memory-activated CD4+ T cell infiltration in colon cancer.
    Journal • Tumor Mutational Burden • IO biomarker
    |
    TMB (Tumor Mutational Burden) • FGFR2 (Fibroblast growth factor receptor 2) • CD4 (CD4 Molecule) • ACTG1 (Actin Gamma 1) • TNFRSF11B (Tumor necrosis factor receptor superfamily member 11B)
    |
    TMB-L • TNFRSF1B overexpression
    almost3years
    Sec62 promotes pro-angiogenesis of hepatocellular carcinoma cells under hypoxia. (PubMed, Cell Biochem Biophys)
    In addition, knockdown of Sec62 inhibited hypoxia-induced tube formation via PAI-1. Sec62 promoted pro-angiogenesis of HCC under hypoxia by regulating PAI-1, and it may be a crucial angiogenic switch in HCC.
    Journal
    |
    TNFA (Tumor Necrosis Factor-Alpha) • TNFRSF11B (Tumor necrosis factor receptor superfamily member 11B)
    |
    TNFRSF1B overexpression • TP53 expression • PAI1 expression