^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    TNFRSF1B (TNF Receptor Superfamily Member 1B)

    i
    Other names: TNFRSF1B, TNF Receptor Superfamily Member 1B, TNFBR, P75, TNF-R-II, TNF-R75, TNFR80, CD120b, TNFR2, Tumor Necrosis Factor Receptor Superfamily Member 1B, Tumor Necrosis Factor Receptor Type II, Tumor Necrosis Factor Receptor, P80 TNF-Alpha Receptor, TNF-RII, TNF-R2, Tumor Necrosis Factor Receptor Superfamily, Member 1B, Tumor Necrosis Factor Binding Protein 2, Tumor Necrosis Factor Beta Receptor, P75 TNF Receptor, CD120b Antigen, Etanercept, P75TNFR, TNFR-II, TNFR1B, TBPII
    Associations

    News

    Trials
    16d
    Accelerated multi-organ proteomic aging is detectable decades before dementia onset. (PubMed, medRxiv)
    Among these is tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), causally implicated in the accelerated pace of brain, immune, muscle, and pancreas aging . Two other proteins associated with pace of brain aging, GM2 ganglioside activator (GM2A) and limbic system-associated membrane protein (LSAMP), showed putative causal roles in multiple neurologic diseases.
    Journal
    |
    TNFA (Tumor Necrosis Factor-Alpha) • TNFRSF1B (TNF Receptor Superfamily Member 1B)
    26d
    Integrative transcriptomic analysis reveals microglial metabolic-inflammatory crosstalk of HK2-HSPA5-TNF axis after intracerebral hemorrhage. (PubMed, Front Bioinform)
    Our multi-omics approach reveals coordinated dysregulation of glucose metabolism and inflammatory genes following ICH, with time-dependent HK2 regulation in microglia and synchronized transcriptional changes at day 7 representing critical events in neuroinflammatory progression. The identified gene networks and cellular communication patterns provide new insights into the metabolic-immune interface in ICH, offering potential targets for future therapeutic strategies.
    Journal
    |
    TNFA (Tumor Necrosis Factor-Alpha) • HK2 (Hexokinase 2) • HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) • TNFRSF1B (TNF Receptor Superfamily Member 1B)
    2ms
    Homoharringtonine suppresses acute myeloid leukemia progression by orchestrating EWSR1 phase separation in an m6A-YTHDF2-dependent mechanism. (PubMed, Imeta)
    In vivo, the anti-leukemic efficacy of HHT was significantly diminished upon EWSR1 knockdown, demonstrating that EWSR1 was required for therapeutic response. Collectively, these findings uncover a phase separation-centric mechanism by which HHT exerts anti-AML activity, establish the EWSR1-YTHDF2-m6A axis as a critical regulator of leukemia progression, and position EWSR1 as both a functional target and a predictive biomarker for optimizing HHT-based therapies.
    Journal
    |
    EWSR1 (EWS RNA Binding Protein 1) • HMOX1 (Heme Oxygenase 1) • YTHDF2 (YTH N6-Methyladenosine RNA Binding Protein 2) • TNFRSF1B (TNF Receptor Superfamily Member 1B)
    |
    Synribo (omacetaxine mepesuccinate)
    4ms
    Activating transcription factor 4-mediated upregulation of Heat Shock Protein Family A Member 4 promotes hepatocellular carcinoma progression through activation of Wnt/β-catenin/EMT signaling pathway. (PubMed, Int J Biol Macromol)
    Knockdown of ATF4 reduced HSPA4 levels and suppressed HCC progression. These findings suggest that HSPA4, regulated by ATF4, may serve as a promising therapeutic target and prognostic biomarker for HCC.
    Journal • IO biomarker
    |
    FLT3 (Fms-related tyrosine kinase 3) • BCL2 (B-cell CLL/lymphoma 2) • ATRX (ATRX Chromatin Remodeler) • SQSTM1 (Sequestosome 1) • DNMT1 (DNA methyltransferase 1) • ATF4 (Activating Transcription Factor 4) • GATA3 (GATA binding protein 3) • RNF31 (Ring Finger Protein 31) • HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4) • MAPK8 (Mitogen-activated protein kinase 8) • TCF4 (Transcription Factor 4) • HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8) • TNFRSF1B (TNF Receptor Superfamily Member 1B)
    4ms
    Tnfrsf1b Protects Zebrafish Against Klebsiella pneumoniae Infection. (PubMed, Infect Drug Resist)
    tnfrsf1b plays a critical role in regulating host immune responses and protecting zebrafish from K. pneumoniae infection. Targeting the tnfrsf1b signaling pathway may represent a promising therapeutic approach for managing infections caused by hypervirulent K. pneumoniae.
    Journal
    |
    IL1B (Interleukin 1, beta) • TNFRSF1B (TNF Receptor Superfamily Member 1B)
    |
    BRAF wild-type
    7ms
    Identification of biomarkers for Laryngeal squamous cell carcinoma through Mendelian randomization and integrated bioinformatics analysis. (PubMed, Discov Oncol)
    This integrative approach comprehensively elucidated the role of pan-apoptosis-related genes in LSCC. The constructed risk model has significant clinical application value in prognostic prediction, immune landscape assessment, and drug sensitivity analysis, and has the potential to guide precision treatment strategies for LSCC patients. These findings may help advance personalized treatment plans and improve the prognosis of patients with LSCC.
    Journal
    |
    TIMP1 (Tissue inhibitor of metalloproteinases 1) • TIMP2 (TIMP Metallopeptidase Inhibitor 2) • PMAIP1 (Phorbol-12-Myristate-13-Acetate-Induced Protein 1) • GATA3 (GATA binding protein 3) • NLRP3 (NLR Family Pyrin Domain Containing 3) • TGFB2 (Transforming Growth Factor Beta 2) • TNFRSF1B (TNF Receptor Superfamily Member 1B)
    |
    birabresib (OTX015) • Jingzhuda (entinostat)
    8ms
    Astroglial TNFR2 signaling regulates hippocampal synaptic function and plasticity in a sex dependent manner. (PubMed, Brain Behav Immun)
    Finally, RNA sequencing of sorted hippocampal astrocytes showed that, in GfapcreERT2:Tnfrsf1bfl/fl male mice, genes and pathways implicated in synaptic plasticity as well as astrocyte-neuron and astrocyte-oligodendrocyte communication were downregulated compared to Tnfrsf1bfl/fl control mice. Together, our findings indicate that TNFR2 signaling in astrocytes is essential for proper astrocyte-neuron communication at the basis of synaptic function, and that this mechanism is regulated in a sex-dependent manner.
    Journal
    |
    TNFA (Tumor Necrosis Factor-Alpha) • TNFRSF1A (TNF Receptor Superfamily Member 1A) • TNFRSF1B (TNF Receptor Superfamily Member 1B)
    8ms
    Fusion of spatiotemporal and network models to prioritize multiscale effects in single-cell perturbations. (PubMed, Brief Bioinform)
    In colitis, Perturb-STNet identified key genes (Csf1r, Col6a1, Lgr4, Myc, and Fzd5) and mediator pairs (Itga5-Flnc, Cd68-Csf1r, Csf1r-Cx3cl1, and Tnfrsf1b-Bmp1) involved in immune regulation, matrix remodeling, and epithelial repair, offering potential therapeutic targets. Overall, Perturb-STNet enables robust identification of spatiotemporal regulatory networks in single-cell perturbation data across diverse disease contexts.
    Journal
    |
    KIT (KIT proto-oncogene, receptor tyrosine kinase) • CD8 (cluster of differentiation 8) • CD79B (CD79b Molecule) • IL2RA (Interleukin 2 receptor, alpha) • CD5 (CD5 Molecule) • CD68 (CD68 Molecule) • CSF1R (Colony stimulating factor 1 receptor) • FOXP3 (Forkhead Box P3) • COL6A1 (Collagen Type VI Alpha 1 Chain) • CX3CL1 (C-X3-C Motif Chemokine Ligand 1) • KLRG1 (Killer Cell Lectin Like Receptor G1) • FLNC (Filamin C) • FZD5 (Frizzled Class Receptor 5) • ITGA5 (Integrin Subunit Alpha 5) • LGR4 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 4) • TNFRSF1B (TNF Receptor Superfamily Member 1B)
    8ms
    Multi-omics insights into biomarkers of breast cancer associated diabetes: a computational approach. (PubMed, Front Med (Lausanne))
    TNF-mediated mechanisms, including NF-κB activation, oxidative stress, and epithelial-to-mesenchymal transition (EMT), were found to drive both diseases, promoting tumorigenesis, immune evasion, and metabolic dysregulation. This study provides critical molecular insights into the shared mechanisms of BC and diabetes, identifying the TNF pathway as a key therapeutic target to improve outcomes for patients with these interconnected conditions.
    Journal
    |
    TNFRSF1B (TNF Receptor Superfamily Member 1B)
    8ms
    Notable influences of estrogen and sex-specific microenvironment in colorectal cancer revealed by single-cell transcriptome analysis. (PubMed, Int J Med Sci)
    Our research highlights the distinct immunological and hormonal responses in CRC by sex, which may explain the observed prognostic disparities. These findings may offer additional further biological insights for targeted therapies in CRC.
    Journal
    |
    CD8 (cluster of differentiation 8) • GZMB (Granzyme B) • MMP11 (Matrix Metallopeptidase 11) • TNFRSF1B (TNF Receptor Superfamily Member 1B)
    8ms
    Glioportal: a comprehensive transcriptomic resource unveiling ligand-mediated mesenchymal transition in glioblastoma. (PubMed, Neuro Oncol)
    Glioportal makes a valuable resource for identifying therapeutic vulnerabilities in molecularly stratified GBM. Here, we underscore GBM dependency on myeloid-derived ligands to acquire mesenchymal traits that has clinical implications in therapeutic response and recurrence. Such reliance warrants treatment strategies targeting ligand-receptor pairs to mitigate interactions with tumour ecosystem.
    Journal
    |
    TNFRSF1A (TNF Receptor Superfamily Member 1A) • TNFRSF1B (TNF Receptor Superfamily Member 1B)
    9ms
    Association of the TNFRSF1B-rs1061622 variant with nonresponse to infliximab in ulcerative colitis. (PubMed, Sci Rep)
    However, for infliximab users only (n = 44), the TNFRSF1B-rs1061622 variant was associated with nonresponse to infliximab for the first time in a cohort of UC patients (p-value = 0.028). Next steps are to replicate this association in independent cohorts and to perform functional studies to gain more evidence on the variant.
    Journal
    |
    TNFAIP3 (TNF Alpha Induced Protein 3) • TNFRSF1B (TNF Receptor Superfamily Member 1B)