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    BIOMARKER:

    TNFRSF17 overexpression

    i
    Other names: TNFRSF17, TNF Receptor Superfamily Member 17, Tumor Necrosis Factor Receptor Superfamily Member 17, B-Cell Maturation Protein, BCMA, Tumor Necrosis Factor Receptor Superfamily, Member 17, B Cell Maturation Antigen, B-Cell Maturation Factor, CD269 Antigen, TNFRSF13A, CD269
    Entrez ID:
    608
    Related biomarkers:
    Expression
    CNA
    Others
    7ms
    The Impact of Soluble BCMA and BCMA Gain on Anti-BCMA Immunotherapies in Multiple Myeloma (ASH 2023)
    Our findings highlight the impact of sBCMA levels and its chronicity of exposure on anti-BCMA TCE and CAR T activities in MM. We further identified structural genomic events driving TNFRSF17 over-expression and their correlation to sBCMA levels facilitating tumoral immunotherapeutic escape.
    IO biomarker
    |
    TNFRSF17 (TNF Receptor Superfamily Member 17) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • IL2RA (Interleukin 2 receptor, alpha) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2) • CD69 (CD69 Molecule) • SDC1 (Syndecan 1) • MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14) • POU2AF1 (POU Class 2 Homeobox Associating Factor 1)
    |
    TNFRSF17 expression • TNFRSF17 deletion • TNFRSF17 overexpression