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    GENE:

    TNFRSF10D (TNF Receptor Superfamily Member 10d)

    i
    Other names: TNFRSF10D, TNF Receptor Superfamily Member 10d, Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy With Truncated Death Domain, Tumor Necrosis Factor Receptor Superfamily Member 10D, TNF-Related Apoptosis-Inducing Ligand Receptor 4, TRAIL Receptor With A Truncated Death Domain, Decoy Receptor 2, TRAIL Receptor 4, TRAIL-R4, TRAILR4, TRUNDD, DCR2, TNF Receptor-Related Receptor For TRAIL, CD264 Antigen, CD264
    1year
    RNA sequencing identifies MAP1A and PTTG1 as predictive genes of aging CD264+ human mesenchymal stem cells at an early passage. (PubMed, Cytotechnology)
    Our findings have application as quality metrics to standardize the composition of MSC therapies and as molecular targets to slow/reverse cellular aging. The online version contains supplementary material available at 10.1007/s10616-025-00724-8.
    Journal
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    PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin) • TNFRSF10D (TNF Receptor Superfamily Member 10d) • MAP1A (Microtubule Associated Protein 1A)
    over1year
    Proteomics-based network pharmacology and molecular docking reveal the potential mechanisms of 5,6,7,4'-tetramethoxyflavone against HeLa cancer cells. (PubMed, Heliyon)
    Notably, p21, p27, EGFR, SMAD4, JNK, ATF2, and c-JUN merged as pivotal targets contributing to TMF's anti-cancer efficacy against HeLa cells. This study is first to delineate the potential signaling pathways and core targets of TMF in treating of HeLa cancer, paving the way for further exploration of TMF's medical potential.
    Journal • IO biomarker
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    EGFR (Epidermal growth factor receptor) • SMAD4 (SMAD family member 4) • IGFBP2 (Insulin-like growth factor binding protein 2) • XIAP (X-Linked Inhibitor Of Apoptosis) • CD40LG (CD40 ligand) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • NFKBIA (NFKB Inhibitor Alpha 2) • STAT2 (Signal transducer and activator of transcription 2) • TNFRSF10B (TNF Receptor Superfamily Member 10b) • TNFRSF10D (TNF Receptor Superfamily Member 10d) • ATF2 (Activating Transcription Factor 2) • FOS (Fos Proto-Oncogene AP-1 Transcription Factor Subunit 2) • HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1) • IGFBP1 (Insulin Like Growth Factor Binding Protein 1) • SMAD2 (SMAD Family Member 2)
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    FASN-L
    over1year
    Tannic acid elicits differential gene regulation in prostate cancer apoptosis. (PubMed, Acta Pharm)
    These findings highlight tannic acid's ability to induce apoptosis in prostate cancer cells through pro-apoptotic pathways. This study concludes that tannic acid selectively inhibits prostate cancer cell growth.
    Journal • IO biomarker
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    TP53 (Tumor protein P53) • BCL2 (B-cell CLL/lymphoma 2) • ATM (ATM serine/threonine kinase) • MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • TNFRSF8 (TNF Receptor Superfamily Member 8) • TNFRSF17 (TNF Receptor Superfamily Member 17) • CHEK2 (Checkpoint kinase 2) • BIRC3 (Baculoviral IAP repeat containing 3) • CD70 (CD70 Molecule) • FASLG (Fas ligand) • BIRC2 (Baculoviral IAP Repeat Containing 2) • CASP3 (Caspase 3) • BCL2A1 (BCL2 Related Protein A1) • CASP8 (Caspase 8) • TNFSF13B (TNF Superfamily Member 13b) • CASP6 (Caspase 6, apoptosis-related cysteine peptidase) • CD40 (CD40 Molecule) • TNFRSF10D (TNF Receptor Superfamily Member 10d) • TNFSF4 (TNF Superfamily Member 4) • TRAF1 (TNF Receptor Associated Factor 1) • PPIA (Peptidylprolyl Isomerase A) • RPA3 (Replication Protein A3)
    over1year
    TNFRSF10D expression as a potential biomarker for cisplatin-induced damage and ovarian tumor relapse prediction. (PubMed, Pathol Res Pract)
    This study aimed to assess the susceptibility of three ovarian tumor cell lines (TOV-21G, SKOV-3, and OV-90) to cisplatin and paclitaxel, and to investigate the influence of these treatments on the mRNA expression of TANK, RIPK1, NFKB1, TNFRSF10D, and TRAF2. In light of this, damage associated with cisplatin increases TNFRSF10D expression and may promote cell survival through non-canonical NFKB pathway activation. This suggests that resistance to TRAIL-induced apoptosis in these cells could serve as a promising chemoresistance biomarker in OC.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • RIPK1 (Receptor Interacting Serine/Threonine Kinase 1) • TNFRSF10D (TNF Receptor Superfamily Member 10d)
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    TNFRSF10D expression
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    cisplatin • paclitaxel
    almost2years
    Exploring novel protein biomarkers for early-stage diagnosis and prognosis of T-acute lymphoblastic leukemia (T-ALL). (PubMed, Hematol Transfus Cell Ther)
    T-ALL patients showed a significant increase in specific disease-related proteins, such as eleven-nineteen lysine-rich leukemia protein, triggering receptor expressed on myeloid cells 1, cisplatin resistance-associated-overexpressed protein, X-ray radiation resistance-associated protein 1, tumor necrosis factor receptor superfamily member 10D, protein S100-A8, and copine-4, by more than 3-fold The findings of this study provide a valuable protein map of leukemic cells and identify potential biomarkers for leukemic aggressiveness. However, further studies using larger T-ALL patient samples must confirm these preliminary results.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • S100A8 (S100 Calcium Binding Protein A8) • TNFRSF10D (TNF Receptor Superfamily Member 10d)
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    cisplatin
    almost3years
    RNA-seq and Single-Cell Transcriptome Analyses of TRAIL Receptors Gene Expression in Human Osteosarcoma Cells and Tissues. (PubMed, Cancer Inform)
    According to the TARGET online database, poor patient outcomes were associated with low expression of TNFRSF10C. These results could provide a new perspective to design novel therapeutic targets of TRAIL receptors for the diagnosis, prognosis and treatment of OS and other cancers.
    Journal
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    TNFRSF10A (TNF Receptor Superfamily Member 10a) • TNFRSF10B (TNF Receptor Superfamily Member 10b) • TNFRSF10D (TNF Receptor Superfamily Member 10d) • TNFRSF10C (TNF Receptor Superfamily Member 10c)
    3years
    Establishment of esophageal squamous carcinoma cell lines with different invasive metastatic potential and differential gene screening. (PubMed, J Physiol Pharmacol)
    The establishment of differential gene expression profiles for invasion and metastasis together with a bioinformatics analysis provided rich information for studies related to ESCC invasion and metastasis. HSP90α, 14-3-3β, and CXCR7 were highly expressed in ESCCs with high invasion and metastasis, while Annexin A1 was highly expressed in ESCCs with low metastasis.
    Preclinical • Journal • Metastases
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    ANXA1 (Annexin A1) • TNFRSF10D (TNF Receptor Superfamily Member 10d) • ACKR3 (Atypical Chemokine Receptor 3) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1) • SDC2 (Syndecan 2)
    over3years
    Escaping cell death via TRAIL decoy receptors: a systematic review of their roles and expressions in colorectal cancer. (PubMed, Apoptosis)
    Additionally, discrepancies between the outcomes from different research groups are discussed, and essential areas are highlighted for future investigation of the roles of decoy receptors in modulating TRAIL-induced apoptosis. Overcoming TRAIL resistance through modulating the expression(s) and elucidating the role(s) of TRAIL decoy receptors hold great promise for TRAIL-based therapies to be extensively explored in treating human cancers including CRC.
    Review • Journal
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    TNFRSF10D (TNF Receptor Superfamily Member 10d) • TNFRSF10C (TNF Receptor Superfamily Member 10c) • TNFRSF11B (Tumor necrosis factor receptor superfamily member 11B)
    over3years
    A Novel L-Phenylalanine Dipeptide Inhibits the Growth and Metastasis of Prostate Cancer Cells via Targeting DUSP1 and TNFSF9. (PubMed, Int J Mol Sci)
    Molecular docking, a cellular thermal shift assay (CETSA), and gene silencing showed that HXL131 had a strong binding affinity with DUSP1 and TNFSF9, which are important target genes for inhibiting the growth and metastasis of PC3 cells. This study demonstrates that HXL131 exhibited excellent anti-prostate cancer activity and inhibited the growth and metastasis of prostate cancer cells by regulating the expression of DUSP1 and TNFSF9.
    Journal
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    IL6 (Interleukin 6) • TIMP1 (Tissue inhibitor of metalloproteinases 1) • TNFRSF10D (TNF Receptor Superfamily Member 10d) • CCN1 (Cellular Communication Network Factor 1) • DUSP1 (Dual Specificity Phosphatase 1) • OSMR (Oncostatin M Receptor) • SOD2 (Superoxide Dismutase 2)
    over3years
    Endogenous TRAIL-R4 critically impacts apoptotic and non-apoptotic TRAIL-induced signaling in cancer cells. (PubMed, Front Cell Dev Biol)
    By inhibiting Bcl-xL with Navitoclax, we could finally show that this protein mainly accounts for the acquired resistance of MDA-MB-231 TRAIL-R4-KD cells to TRAIL-induced apoptosis...Importantly, in both cell lines the activity of AKT, ERK, p38 and NF-κB after TRAIL treatment was higher in TRAIL-R4-KD cells than in respective control cells. Thus, our data provide evidence for the important regulatory functions of endogenous TRAIL-R4 in cancer cells and improve our understanding of the very complex human TRAIL/TRAIL-R system.
    Journal
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    BCL2L1 (BCL2-like 1) • BIRC3 (Baculoviral IAP repeat containing 3) • TNFRSF10A (TNF Receptor Superfamily Member 10a) • XIAP (X-Linked Inhibitor Of Apoptosis) • TNFRSF10B (TNF Receptor Superfamily Member 10b) • TNFRSF10D (TNF Receptor Superfamily Member 10d)
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    navitoclax (ABT 263)