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    BIOMARKER:

    TNFRSF10D expression

    i
    Other names: TNFRSF10D, TNF Receptor Superfamily Member 10d, Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy With Truncated Death Domain, Tumor Necrosis Factor Receptor Superfamily Member 10D, TNF-Related Apoptosis-Inducing Ligand Receptor 4, TRAIL Receptor With A Truncated Death Domain, Decoy Receptor 2, TRAIL Receptor 4, TRAIL-R4, TRAILR4, TRUNDD, DCR2, TNF Receptor-Related Receptor For TRAIL, CD264 Antigen, CD264
    Entrez ID:
    8793
    over3years
    Integrated analysis of mRNA and miRNA profiles revealed the role of miR-193 and miR-210 as potential regulatory biomarkers in different molecular subtypes of breast cancer. (PubMed, BMC Cancer)
    In summary, our findings identify miR-193 and miR-210 as potential regulatory miRNA in different molecular subtypes of breast cancer and suggest that miR-210 may have a specific role in MDA-MB-231 proliferation. Our results highlight important new downstream regulated targets that may serve as promising therapeutic pathways for aggressive breast cancers.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2) • CCND1 (Cyclin D1) • TNFRSF10D (TNF Receptor Superfamily Member 10d)
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    CCND1 expression • TNFRSF10D expression
    over3years
    Zinc-finger antiviral protein acts as a tumor suppressor in colorectal cancer. (PubMed, Oncogene)
    Furthermore, our CRISPR-engineered mice models show that loss-of-function of ZAP synergizes with APC-deficiency to drive malignant colorectal cancer in vivo. Overall, we identify a previously unknown function of the antiviral factor ZAP in colorectal tumorigenesis, linking intrinsic immunity to tumor pathogenetics.
    Journal
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    TNFRSF10D (TNF Receptor Superfamily Member 10d)
    |
    TNFRSF10D expression