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    GENE:

    TNFRSF10C (TNF Receptor Superfamily Member 10c)

    i
    Other names: TNFRSF10C, TNF Receptor Superfamily Member 10c, TRAILR3, TRID, LIT, CD263, DcR1, Tumor Necrosis Factor Receptor Superfamily, Member 10c, Decoy Without An Intracellular Domain, Tumor Necrosis Factor Receptor Superfamily Member 10C, TNF-Related Apoptosis-Inducing Ligand Receptor 3, Antagonist Decoy Receptor For TRAIL/Apo-2L, Decoy TRAIL Receptor Without Death Domain, Lymphocyte Inhibitor Of TRAIL, Decoy Receptor 1, TRAIL-R3, DCR1, TRAIL Receptor Without An Intracellular Domain, Cytotoxic TRAIL Receptor-3, TRAIL Receptor 3, CD263 Antigen, DCR1-TNFR
    Associations

    News

    Trials
    3ms
    Temozolomide-induced senescent glioblastoma cells acquire sensitivity to TRAIL death receptor 5-mediated apoptosis. (PubMed, Med Oncol)
    These findings suggest that TMZ-induced senescence enhances glioblastoma cell sensitivity to DR5 receptor agonists. However, when developing strategies for senolytic antitumor therapy, the heterogeneous response of tumor cells to senescence induction should be taken into account.
    Journal
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    TP53 (Tumor protein P53) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • CFLAR (CASP8 and FADD-like apoptosis regulator) • TNFRSF10B (TNF Receptor Superfamily Member 10b) • TNFRSF10C (TNF Receptor Superfamily Member 10c)
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    TP53 mutation
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    temozolomide
    4ms
    Transcription-replication conflict resolution by nuclear RNA interference. (PubMed, Mol Cell)
    The RNase H homolog Argonaute (Ago1) promotes genome instability by binding R-loops, and its removal relieves replication stress. Analysis of replication intermediates, DNA and RNA 3' ends, and fork processivity genome wide indicates Dicer resolves head-on T-R collisions, consistent with an ancient origin in DNA replication.
    Journal
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    TNFRSF10C (TNF Receptor Superfamily Member 10c)
    4ms
    Neutrophil extracellular trap-related signature predicts the prognosis and immunotherapy outcome of lung adenocarcinoma. (PubMed, Genomics)
    Finally, we found that MEK inhibitors (selumetinib and trametinib) were more sensitive in the NET-high group and can inhibit the invasion and migration of LUAD cells. The NETs-related signature was able to predict the prognosis and immunotherapy outcome of LUAD patients.
    Journal • Tumor mutational burden • IO biomarker
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    TMB (Tumor Mutational Burden) • BST1 (Bone Marrow Stromal Cell Antigen 1) • ATG7 (Autophagy Related 7) • TNFRSF10C (TNF Receptor Superfamily Member 10c)
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    TMB-H
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    Mekinist (trametinib) • Koselugo (selumetinib)
    5ms
    Association between coronary thrombus composition and microvascular obstruction following percutaneous coronary intervention in patients with acute myocardial infarction: A proof-of-concept study. (PubMed, Medicine (Baltimore))
    Quantitative analysis of coronary thrombus components revealed significant positive correlations between sCD40-L, hs-CRP, VCAM-1 levels and CMVO prevalence. Moreover, systemic metabolic disturbances - particularly type 2 diabetes mellitus, elevated serum LDL-C concentrations and heightened IL-6 levels were identified as independent predisposing factors for CMVO development.
    Observational data • Journal • IO biomarker
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • GDF15 (Growth differentiation factor 15) • TNFRSF1A (TNF Receptor Superfamily Member 1A) • CD40LG (CD40 ligand) • VCAM1 (Vascular Cell Adhesion Molecule 1) • CRP (C-reactive protein) • TNFRSF10C (TNF Receptor Superfamily Member 10c) • ESM1 (Endothelial Cell Specific Molecule 1)
    5ms
    The OvarianTag™ Biomarker Panel Emerges as a Prognostic Tool to Guide Clinical Decisions in Cisplatin-Based Treatment of Epithelial Ovarian Cancer. (PubMed, Int J Mol Sci)
    This molecular assay has the potential to guide personalized treatment strategies, enhancing clinical decision-making and improving patient outcomes. Further validation in independent cohorts is warranted to establish its clinical utility.
    Observational data • Journal
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    CASP8 (Caspase 8) • TNFRSF10B (TNF Receptor Superfamily Member 10b) • TNFRSF10C (TNF Receptor Superfamily Member 10c)
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    cisplatin
    9ms
    Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms. (PubMed, Discov Oncol)
    These findings indicate that the potent anticancer effects of eugenol are primarily driven by its ability to reduce oxidative stress, suppress inflammation, and inhibit cell proliferation while promoting apoptosis. This study underscores the potential of eugenol as a promising therapeutic agent for the prevention and management of HCC, offering a novel approach to HCC treatment.
    Journal • IO biomarker
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    KRAS (KRAS proto-oncogene GTPase) • TP53 (Tumor protein P53) • HRAS (Harvey rat sarcoma viral oncogene homolog) • TNFA (Tumor Necrosis Factor-Alpha) • CEACAM5 (CEA Cell Adhesion Molecule 5) • NFE2L2 (Nuclear Factor, Erythroid 2 Like 2) • AFP (Alpha-fetoprotein) • BAX (BCL2-associated X protein) • CXCR3 (C-X-C Motif Chemokine Receptor 3) • IL1B (Interleukin 1, beta) • TNFRSF10B (TNF Receptor Superfamily Member 10b) • TNFRSF10C (TNF Receptor Superfamily Member 10c) • IQGAP1 (IQ Motif Containing GTPase Activating Protein 1)
    9ms
    The Combination of PF-543 and TRAIL Effectively Induces Apoptotic Cell Death and Inhibits Stem Cell-Like Properties Through the SPHK1/S1PR1/STAT3 Pathway in TRAIL-Resistant Colorectal Cancer Cells. (PubMed, Dig Dis Sci)
    We identified the molecular mechanisms underlying acquired TRAIL resistance in CRC cells and suggest that targeting SPHK1 represents a potential strategy to overcome TRAIL resistance and inhibit CRC metastasis.
    Journal
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    S1PR1 (Sphingosine-1-Phosphate Receptor 1) • SPHK1 (Sphingosine Kinase 1) • TNFRSF10C (TNF Receptor Superfamily Member 10c)
    10ms
    Feature Selection for Classification based on Machine Learning algorithms for Prostate Cancer. (PubMed, Biomed Phys Eng Express)
    Random Forest classification algorithm outperforms other classification methods. The significant genes that has the major influence in prostate cancer disease are identified such as KLK3, GFI1, CXCR2 and TNFRSF10C.
    Journal
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    CXCR2 (Chemokine (C-X-C motif) receptor 2) • KLK3 (Kallikrein-related peptidase 3) • TNFRSF10C (TNF Receptor Superfamily Member 10c)
    11ms
    The neutrophil extracellular trap-related gene FPR1 (formyl peptide receptor 1) as a potential prognostic and therapeutic target in osteosarcoma. (PubMed, BMC Musculoskelet Disord)
    Collectively, our study indicates that the NET-related gene FPR1 is closely related to tumor progression, prognosis and immune infiltration in OS.
    Journal
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    BST1 (Bone Marrow Stromal Cell Antigen 1) • TNFRSF10C (TNF Receptor Superfamily Member 10c)
    12ms
    Molecular profiling of breast cancer methylation pattern in triple negative versus non- triple negative breast cancer. (PubMed, Sci Rep)
    The hypermethylation of BRCA1 and GSTP were independent predictors of DFS, while PTEN hypermethylation was an independent predictor of OS in the TNBC cohort. The identification of hypermethylated genes, such as BRCA1, CCND2, CDH1, ESR1, GSTP, RASSF1, SLIT2, MGMT, and PTEN may serve as potential biomarkers or therapeutic targets for TNBC.
    Journal • BRCA Biomarker
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    ER (Estrogen receptor) • BRCA1 (Breast cancer 1, early onset) • PTEN (Phosphatase and tensin homolog) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • CDH1 (Cadherin 1) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • CCND2 (Cyclin D2) • RASSF1 (Ras Association Domain Family Member 1) • SLIT2 (Slit Guidance Ligand 2) • TP73 (Tumor Protein P73) • CCNA1 (Cyclin A1) • HIC1 (HIC ZBTB Transcriptional Repressor 1) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA) • PYCARD (PYD And CARD Domain Containing) • TNFRSF10C (TNF Receptor Superfamily Member 10c)
    over1year
    Investigation of risk signatures associated with anoikis in thyroid cancer through integrated transcriptome and Mendelian randomization analysis. (PubMed, Front Endocrinol (Lausanne))
    Furthermore, real-time quantitative polymerase chain reaction (RT-qPCR) confirmed the upregulated expression patterns of these prognostic genes in THCA tissues. In conclusion, we constructed the risk signature related to anoikis for THCA, which might have important clinical significance for improving the quality of life and treatment effect of THCA patients.
    Journal • IO biomarker
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    CXCL8 (Chemokine (C-X-C motif) ligand 8) • TPD52L1 (Tumor protein D53) • TNFRSF10C (TNF Receptor Superfamily Member 10c)
    over1year
    UNIVERSE: Clinical Study of the Efficacy and Safety of BCD-263 and Opdivo® As Monotherapy in Subjects with Advanced Melanoma of the Skin (clinicaltrials.gov)
    P3, N=392, Recruiting, Biocad
    New P3 trial • Metastases
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    TNFRSF10C (TNF Receptor Superfamily Member 10c)
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    Opdivo (nivolumab)