TNFA (Tumor Necrosis Factor-Alpha)

Both groups showed a great decrease in TNF-α and IL-6 levels post-treatment (P < 0.05), with TG demonstrating lower levels of TNF-α, IL-6, PI3K, and AKT proteins relative to CG (P < 0.05). JJWT effectively reduced microbial colony counts in diabetic foot patients, markedly suppressed the expression of TNF-α and IL-6, and enhanced wound healing by modulating PI3K/Akt SPW, indicating strong antibacterial and anti-inflammatory properties of Jiangjunsan.

Moreover, 6-OHDA induces distinct inflammatory responses depending on the stage of oligodendrocyte differentiation. These findings highlight the dual role of oligodendrocytes as both iron reservoirs and modulators of the neuroinflammatory microenvironment, providing new insights into the cellular mechanisms underlying nigral iron accumulation in PD, and suggesting that oligodendrocytes play a critical regulatory role in PD pathogenesis.

Furthermore, CUR@HA-C60 demonstrated favorable biosafety profiles in murine models and significantly improved CUR bioavailability by suppressing inflammation, reducing OS-related damage, and restoring intestinal epithelial integrity. These findings indicate that CUR@HA-C60 represents a promising oral therapeutic strategy for the treatment of inflammatory diseases.

The 5 mg/kg dose provided the most consistent benefit. These findings suggest that quercetin, particularly at 5 mg/kg, could serve as a potential adjunctive therapy to mitigate neurotoxic side effects associated with RT.

This study establishes a novel combinatorial strategy utilizing CD205-targeted, tumor cell-derived NVs as a DC vaccine to effectively reprogram the immunosuppressive TME. CAR-T + Vac therapy significantly enhances CAR-T cell infiltration and antitumor efficacy against lung cancer, providing a versatile and promising platform for advancing solid tumor immunotherapy.

Our meta-analysis showed that INI is a promising therapy for reducing the incidence of POD and POCD as well as decreasing postoperative inflammatory factors. However, more multicenter studies outside China, with large sample sizes are needed to determine the optimal formulation, dose, timing, and frequency of INI.

This study highlights CaMnP1000 as a biomaterial with enhanced osteogenic, angiogenic and possibly inflammatory properties. Future research should focus on the underlying mechanisms and manganese-doped CaPs for therapeutic purposes in bone healing.

This assay enables manufacturers and regulators to meet the growing demand for reliable impurity screening assays that support the characterization of vaccines activating the NF-κB pathway. Future studies must further characterise NF-κB activation by individual TLRs across a broader range of vaccines.

MSK AEs represent a common, under-recognized toxicity affecting nearly one-third of BCMA CAR-T recipients, often causing severe and prolonged disability. The identification of predictive baseline PMN-MDSC reduction and persistent inflammatory cytokine elevation provides insights into pathophysiology and suggests potential for risk stratification and targeted therapeutic intervention. These findings warrant prospective validation and development of standardized assessment and management protocols.

Xanthoxylin (XT; 2‑hydroxy‑4,6-dimethoxyacetophenone), a phenolic acetophenone from Zanthoxylum spp., exhibits anti-inflammatory efficacy through regulating both F4/80loCD11b+ macrophage infiltration and the TNF/NF-κB pathway, positioning it as a promising agent for UC.

NAM is getting attention for its crucial and cost-effective role in preventing the adverse effects of gamma irradiation, this might encourage the use of NAM as a radio-protective agent on a potentially large scale.

Hydrocotyle asiatica extract specifically modulates key metabolic and transcriptional pathways involved in intestinal integrity. These findings provide valuable insights into the mechanisms by which HAE preserves intestinal barrier function and underscore its potential application in enhancing intestinal barrier integrity, which may be relevant for managing food allergies and intestinal inflammatory disorders in clinical settings.