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    BIOMARKER:

    TNFA-H

    i
    Other names: Tumor Necrosis Factor, Tumor Necrosis Factor Ligand Superfamily Member 2, Cachectin, TNF-Alpha, TNFSF2, TNF-A, TNFA, Tumor Necrosis Factor (TNF Superfamily, Member 2), Tumor Necrosis Factor Ligand 1F, Tumor Necrosis Factor-Alpha, TNF Superfamily, Member 2, TNF Macrophage-Derived, TNF Monocyte-Derived, APC1 Protein, TNLG1F
    Entrez ID:
    405785
    Related biomarkers:
    Expression
    Others
    Associations

    News

    Trials
    2years
    TNFR2 HuGEMMTM murine model for evaluation of hTNFα-hTNFR2 signaling effect on induced regulatory T cell differentiation (SITC 2022)
    In vitro iTreg differentiation assay can be used to evaluate the drug candidate’s effect on hTNFa-hTNFR2 signaling. These data also suggest that TNFa-TNFR2 signaling plays an important inhibitory role on iTreg differentiation, while it has no obvious effect on iTreg suppressive function on T cell proliferation.
    Preclinical • IO biomarker
    |
    TNFA (Tumor Necrosis Factor-Alpha) • CD4 (CD4 Molecule)
    |
    TNFA-H
    2years
    Comprehensive immune profiling of patients with advanced urothelial or renal cell carcinoma receiving immune checkpoint blockade. (PubMed, Front Oncol)
    Its dynamic changes during treatment may be used to assess response before radiographic changes are apparent, and these changes may help us delineate mechanisms that underpin both response and resistance to ICI. It also hypothesizes a potential role for γ/δ T cells as effector cells in some cases.
    Journal • Checkpoint inhibition • PD(L)-1 Biomarker • IO biomarker
    |
    PD-1 (Programmed cell death 1) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • CCR4 (C-C Motif Chemokine Receptor 4) • CD4 (CD4 Molecule) • CCR7 (Chemokine (C-C motif) receptor 7) • KLRB1 (Killer Cell Lectin Like Receptor B1)
    |
    CXCR4 expression • TNFA-H
    over2years
    TNFAIP6 Promotes Gastric Carcinoma Cell Invasion via Upregulating PTX3 and Activating the Wnt/β-Catenin Signaling Pathway. (PubMed, Contrast Media Mol Imaging)
    Mechanistically, overexpression of TNFAIP6 raised β-catenin ectopic nuclear distribution and activated the Wnt/β-catenin signal pathway. The experimental results show that TNFAIP6 facilitates the aggressive potential of GC cells through modulating PTX3 expression.
    Journal
    |
    TNFA (Tumor Necrosis Factor-Alpha)
    |
    TNFA-H