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    BIOMARKER:

    TNC overexpression

    i
    Other names: TNC, Tenascin C, TN, HXB, Glioma-Associated-Extracellular Matrix Antigen, Deafness, Autosomal Dominant 56, Hexabrachion (Tenascin), Myotendinous Antigen, Neuronectin, GP 150-225, Cytotactin, MGC167029, Tenascin, DFNA56, GMEM, TN-C, JI, Hexabrachion (Tenascin C, Cytotactin), Tenascin-C Additional Domain 1, Hexabrachion, Tenascin-C, 150-225, GP
    Entrez ID:
    3371
    2years
    Tenascin C in pancreatic cancer-associated fibroblasts enhances epithelial mesenchymal transition and is associated with resistance to immune checkpoint inhibitor. (PubMed, Am J Cancer Res)
    Patients with high TNC expression and high ITGαV or ITGB3 expression were associated with poor response to ICI therapy. In conclusion, these findings suggest that TNC-high CAFs play a crucial role in tumor progression and resistance to ICI therapy in PAAD patients, and targeting TNC and its interactions with cancer cells may provide a potential strategy for improving the efficacy of ICI therapy in PAAD.
    Journal • Checkpoint inhibition • IO biomarker
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    ITGB3 (Integrin Subunit Beta 3)
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    TNC overexpression
    over2years
    Evaluating nanoparticle localisation in glioblastoma multicellular tumour spheroids by surface enhanced Raman scattering. (PubMed, Analyst)
    Here, we focus on the localisation of the NPs after incubation into pre-formed MTS to establish a better understanding of targeting and NP uptake. Therefore, this work highlights the importance for the investigation and translation of NP uptake into these 3D in vitro models.
    Journal
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    TNC overexpression