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    GENE:

    TMX4 (Thioredoxin Related Transmembrane Protein 4)

    i
    Other names: TMX4, Thioredoxin Related Transmembrane Protein 4, Thioredoxin-Related Transmembrane Protein 4, DJ971N18.2, KIAA1162, TXNDC13, PDIA14, Protein Disulfide Isomerase Family A, Member 14, Thioredoxin Domain-Containing Protein 13, Thioredoxin Domain Containing 13
    Associations

    News

    Trials
    1year
    Study on the correlation between the transmembrane disulfide isomerase TMX1 and TMX4 and delayed encephalopathy caused by carbon monoxide poisoning (ChiCTR2400091657)
    P4, N=90, Recruiting, Shanxi Bethune Hospital; Shanxi Bethune Hospital
    New P4 trial
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    TMX4 (Thioredoxin Related Transmembrane Protein 4)
    almost2years
    Construction of a prognostic model with CAFs for predicting the prognosis and immunotherapeutic response of lung squamous cell carcinoma. (PubMed, J Cell Mol Med)
    We constructed a CAF prognostic signature for identifying potential prognostic CAFRGs and predicting the prognosis and immunotherapeutic response for LUSC. Our study may provide a more accurate prognostic assessment and immunotherapy targeting strategies for LUSC.
    Journal • IO biomarker
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    CLDN1 (Claudin 1) • TMX4 (Thioredoxin Related Transmembrane Protein 4) • TNFRSF12A (TNF Receptor Superfamily Member 12A)
    almost4years
    Estrogen receptor beta promotes lung cancer invasion via increasing CXCR4 expression. (PubMed, Cell Death Dis)
    The preclinical study using an in vivo mouse model with orthotopic xenografts of NSCLC cells confirmed the in vitro data, and the human NSCLC database analysis and tissue staining also confirmed the linkage of ERβ/miR-622/CXCR4 signaling to the NSCLC progression. Together, our findings suggest that ERβ can promote NSCLC cell invasion via altering the ERβ/circ-TMX4/miR-622/CXCR4 signaling, and targeting this newly circ-TMX4/miR-622/CXCR4 signaling may help us find new treatment strategies to better suppress NSCLC progression.
    Journal
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    ER (Estrogen receptor) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • MIR622 (MicroRNA 622) • TMX4 (Thioredoxin Related Transmembrane Protein 4)
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    CXCR4 expression