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    BIOMARKER:

    TMPRSS11E expression

    i
    Other names: TMPRSS11E, Transmembrane Serine Protease 11E, DESC1, TMPRSS11E2, Transmembrane Protease, Serine 11E, Transmembrane Protease Serine 11E2, Transmembrane Protease Serine 11E, Serine Protease DESC1, Transmembrane Protease, Serine 11E2
    Entrez ID:
    28983
    1year
    And-Gate CAR T-Cells to Improve Tumour Specificity and Targeting of Low-Expression Antigens in Multiple Myeloma (ASH 2023)
    In summary, our work suggests that AND-gate targeting can increase not just specificity, but potency, even against very low expression tumour targets in MM. Link to preprint https://doi.org/10.1101/2023.04.04.535580
    CAR T-Cell Therapy • IO biomarker
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    TNFRSF8 (TNF Receptor Superfamily Member 8) • IFNG (Interferon, gamma) • CD69 (CD69 Molecule) • IL2 (Interleukin 2) • TMPRSS11E (Transmembrane Serine Protease 11E) • HTRA1 (HtrA Serine Peptidase 1)
    |
    TNFRSF8 expression • IFNG expression • IL2 expression • TMPRSS11E expression