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    GENE:

    TMEM87A (Transmembrane Protein 87A)

    i
    Other names: TMEM87A, Transmembrane Protein 87A, DKFZP564G2022
    over1year
    Transmembrane proteins with unknown function (TMEMs) as ion channels: electrophysiological properties, structure, and pathophysiological roles. (PubMed, Exp Mol Med)
    Furthermore, we discuss the diverse physiological roles of these proteins in lysosomal/endosomal/Golgi pH regulation, intracellular Ca2+ regulation, spatial memory, cell migration, adipocyte differentiation, and mechanical pain, as well as their pathophysiological roles in Parkinson's disease, cancer, osteogenesis imperfecta, infantile hypomyelination, cardiomyopathy, and auditory neuropathy spectrum disorder. This review highlights the potential for the discovery of novel ion channels within the TMEM protein family and the development of new therapeutic targets for related channelopathies.
    Review • Journal
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    ANO1 (Anoctamin 1) • TMEM87A (Transmembrane Protein 87A)
    2years
    CircTMEM87A promotes the tumorigenesis of gastric cancer by regulating the miR-1276/SLC7A11 axis. (PubMed, J Gastroenterol Hepatol)
    CircTMEM87A promoted the proliferation and migration and inhibited apoptosis and ferroptosis of GC cells by increasing SLC7A11 expression through binding to miR-1276.
    Journal
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    CDH1 (Cadherin 1) • VIM (Vimentin) • SLC7A11 (Solute Carrier Family 7 Member 11) • TMEM87A (Transmembrane Protein 87A) • MIR127 (MicroRNA 127) • MIR1276 (MicroRNA 1276)
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    CDH1 expression • SLC7A11 expression • VIM expression