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    GENE:

    TMEM217 (Transmembrane Protein 217)

    i
    Other names: TMEM217, Transmembrane Protein 217, DJ355M6.2, C6orf128, Chromosome 6 Open Reading Frame 128
    almost5years
    [VIRTUAL] Loss of 5'ALK leads to better response to crizotinib in sarcomas with ALK rearrangement. (ASCO 2021)
    We report here 4 sarcomas with ALK rearrangement, including a novel fusion TMEM217-ALK . Two of these cases had a 5'ALK loss in addition to the 3'ALK rearrangement, and both had much longer PFS on Crizotinib therapy . The underlying mechanism deserved further investigation .
    ALK (Anaplastic lymphoma kinase) • EML4 (EMAP Like 4) • RANBP2 (RAN Binding Protein 2) • PLEKHH2 (Pleckstrin Homology, MyTH4 And FERM Domain Containing H2) • TMEM217 (Transmembrane Protein 217)
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    ALK positive • ALK rearrangement • EML4-ALK fusion • ALK fusion • RANBP2-ALK fusion • PLEKHH2-ALK rearrangement • RANBP2-ALK + TMEM217-ALK
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    VENTANA ALK (D5F3) CDx Assay
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    Xalkori (crizotinib)