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    GENE:

    TM6SF1 (Transmembrane 6 Superfamily Member 1)

    i
    Other names: TM6SF1, Transmembrane 6 Superfamily Member 1
    Associations

    News

    Trials
    almost2years
    TM6SF1 suppresses the progression of lung adenocarcinoma and M2 macrophage polarization by inactivating the PI3K/AKT/mtor pathway. (PubMed, Biochem Biophys Res Commun)
    TM6SF1-caused inhibition of proliferation, migration, invasion and EMT, as M2 macrophage polarization was reversed by the PI3K activator in LUAD cells. TM6SF1 inactivated the PI3K/AKT/mTOR pathway to suppress LUAD malignancy and polarization of M2 macrophages, providing insight for developing new LUAD treatments.
    Journal
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    CDH1 (Cadherin 1) • CD163 (CD163 Molecule) • IL10 (Interleukin 10) • MMP2 (Matrix metallopeptidase 2) • VIM (Vimentin) • CDH2 (Cadherin 2) • MMP9 (Matrix metallopeptidase 9) • MRC1 (Mannose Receptor C-Type 1) • TM6SF1 (Transmembrane 6 Superfamily Member 1)
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    CDH1 expression • MRC1 expression
    3years
    Carboplatin and Nab-Paclitaxel With or Without Vorinostat in Treating Women With Newly Diagnosed Operable Breast Cancer (clinicaltrials.gov)
    P2, N=68, Active, not recruiting, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Trial completion date: Feb 2023 --> Feb 2024
    Trial completion date
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    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor) • RASSF1 (Ras Association Domain Family Member 1) • ARHGEF7 (Rho Guanine Nucleotide Exchange Factor 7) • COL6A2 (Collagen Type VI Alpha 2 Chain) • GPX7 (Glutathione Peroxidase 7) • HOXB4 (Homeobox B4) • RASGRF2 (Ras Protein Specific Guanine Nucleotide Releasing Factor 2) • TM6SF1 (Transmembrane 6 Superfamily Member 1)
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    ER positive • HER-2 negative • PGR negative
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    carboplatin • albumin-bound paclitaxel • Zolinza (vorinostat)
    3years
    Investigation of M2 macrophage-related gene affecting patients prognosis and drug sensitivity in non-small cell lung cancer: Evidence from bioinformatic and experiments. (PubMed, Front Oncol)
    Meanwhile, the estimated IC50 of seven drugs differs significantly between two risk groups, including Cisplatin, Docetaxel, Doxorubicin, Gefitinib, Paclitaxel, Sunitinib and Vinorelbine. In summary, our study identified the molecules significantly affecting M2 macrophage infiltration and identified a prognosis signature that robustly indicated patients prognosis. Moreover, we validated the cancer-promoting effect of HNMT using in vitro experiments.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    CAPZA2 (Capping Actin Protein Of Muscle Z-Line Subunit Alpha 2) • HS3ST2 (Heparan Sulfate-Glucosamine 3-Sulfotransferase 2) • TM6SF1 (Transmembrane 6 Superfamily Member 1)
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    cisplatin • gefitinib • paclitaxel • docetaxel • sunitinib • doxorubicin hydrochloride • vinorelbine tartrate
    over3years
    Identification and Validation of a GPX4-Related Immune Prognostic Signature for Lung Adenocarcinoma. (PubMed, J Oncol)
    Furthermore, greater sensitivity to erlotinib and lapatinib were identified in the low-risk cohort based on the GDSC database. Our findings suggest that the GPS can effectively forecast the prognosis of LUAD patients and may possibly regulate the TME of LUAD.
    Journal
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    GPX4 (Glutathione Peroxidase 4) • LATS2 (Large Tumor Suppressor Kinase 2) • TM6SF1 (Transmembrane 6 Superfamily Member 1)
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    erlotinib • lapatinib
    4years
    Carboplatin and Nab-Paclitaxel With or Without Vorinostat in Treating Women With Newly Diagnosed Operable Breast Cancer (clinicaltrials.gov)
    P2, N=68, Active, not recruiting, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Trial completion date: Feb 2022 --> Feb 2023
    Trial completion date
    |
    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor) • RASSF1 (Ras Association Domain Family Member 1) • ARHGEF7 (Rho Guanine Nucleotide Exchange Factor 7) • COL6A2 (Collagen Type VI Alpha 2 Chain) • GPX7 (Glutathione Peroxidase 7) • HOXB4 (Homeobox B4) • RASGRF2 (Ras Protein Specific Guanine Nucleotide Releasing Factor 2) • TM6SF1 (Transmembrane 6 Superfamily Member 1)
    |
    ER positive • HER-2 negative • PGR negative
    |
    carboplatin • albumin-bound paclitaxel • Zolinza (vorinostat)