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    BIOMARKER:

    TM4SF19 expression

    i
    Other names: TM4SF19, Transmembrane 4 L Six Family Member 19, Osteoclast Maturation-Associated Gene 4 Protein, Transmembrane 4 L6 Family Member 19, Tetraspan Membrane Protein OCTM4, OCTM4, TM4SF19
    Entrez ID:
    116211
    almost3years
    TM4SF19 regulates oxidative stress-dependent YAP transcription in HNSCC (AACR 2023)
    We further show that TM4SF19 knockdown significantly reduces key characteristics of malignant cells, such as active proliferation and migration. Our results suggest that TM4SF19 is not only a novel transcriptional regulator of YAP but also a strong therapeutic target to suppress the oncogenic activity of YAP, and also provide new clue to understand HNSCC tumorigenesis involving YAP and oxidative stress.
    Oxidative stress
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    YAP1 (Yes associated protein 1) • TM4SF1 (Transmembrane 4 L Six Family Member 1) • TM4SF19 (Transmembrane 4 L Six Family Member 19)
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    TM4SF19 expression
    over3years
    LncRNA TM4SF19-AS1 exacerbates cell proliferation, migration, invasion, and EMT in head and neck squamous cell carcinoma via enhancing LAMC1 expression. (PubMed, Cancer Biol Ther)
    Rescue assays confirmed that TM4SF19-AS1 contributed to HNSCC cell malignant behaviors via up-regulating LAMC1. To summarize, TM4SF19-AS1 played an oncogenic role in HNSCC cells, signifying TM4SF19-AS1 may have the potential to be used as a novel molecular target for HNSCC diagnosis.
    Journal
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    TM4SF1 (Transmembrane 4 L Six Family Member 1) • TM4SF19 (Transmembrane 4 L Six Family Member 19) • HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C) • LAMC1 (Laminin Subunit Gamma 1)
    |
    TM4SF1 expression • TM4SF19 expression