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    BIOMARKER:

    TM4SF1 overexpression

    i
    Other names: TM4SF1, Transmembrane 4 L Six Family Member 1, Transmembrane 4 Superfamily Member 1, Transmembrane 4 L6 Family Member 1, Tumor-Associated Antigen L6, TAAL6, M3S1, L6, Membrane Component Chromosome 3 Surface Marker 1, Membrane Component Chromosome 3 Surface Marker 1, H-L6
    Entrez ID:
    4071
    Related biomarkers:
    Expression
    10ms
    PLAU promotes growth and attenuates cisplatin chemosensitivity in ARID1A-depleted non-small cell lung cancer through interaction with TM4SF1. (PubMed, Biol Direct)
    Taken together, PLAU serves as a target gene of ARID1A and promotes NSCLC growth, survival, and cisplatin resistance by stabilizing TM4SF1. Targeting TM4SF1 may be a promising therapeutic strategy for ARID1A-mutated NSCLC.
    Journal
    |
    ARID1A (AT-rich interaction domain 1A) • IFIT3 (Interferon Induced Protein With Tetratricopeptide Repeats 3) • TM4SF1 (Transmembrane 4 L Six Family Member 1) • PLAU (Plasminogen Activator)
    |
    ARID1A mutation • TM4SF1 expression • TM4SF1 overexpression
    |
    cisplatin
    over2years
    TM4SF1 promotes glioma malignancy through multiple mechanisms. (PubMed, Neoplasma)
    Mechanistically, we found that loss of TM4SF1 reduced phospho-ATK, Cyclin D1, Bcl-2, and MMP9 levels in glioma cells. Taken together, these findings provide novel insights into glioma pathogenesis and suggest that TM4SF1 may represent a novel target for glioma intervention.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • CCND1 (Cyclin D1) • IFIT3 (Interferon Induced Protein With Tetratricopeptide Repeats 3) • MMP9 (Matrix metallopeptidase 9) • TM4SF1 (Transmembrane 4 L Six Family Member 1)
    |
    TM4SF1 expression • TM4SF1 overexpression
    over2years
    Hyper-expression and hypomethylation of TM4SF1 are associated with lymph node metastases in papillary thyroid carcinoma patients. (PubMed, Neoplasma)
    MSP exhibited that the positive rate of aberrant promoter methylation of TM4SF1 was 8.38% in N1 and 66.7% in N0 group (p < 0.05). Hyper-expression and hypomethylation of TM4SF1 are associated with lymph node metastases in PTC patients.
    Retrospective data • Journal
    |
    IFIT3 (Interferon Induced Protein With Tetratricopeptide Repeats 3) • TM4SF1 (Transmembrane 4 L Six Family Member 1)
    |
    TM4SF1 expression • TM4SF1 overexpression
    over2years
    Transmembrane 4 L Six Family Member 1 Suppresses Hormone Receptor--Positive, HER2-Negative Breast Cancer Cell Proliferation. (PubMed, Front Pharmacol)
    In vivo, the TM4SF1 overexpression inhibited MCF-7 xenograft growth in a nude mouse model, which was associated with the downregulation of the Ki-67 expression, apoptosis induction, and inhibition of the mTOR pathway. TM4SF1 is downregulated in HR + HER2-breast cancer, and the overexpression of TM4SF1 suppresses cell proliferation in this cancer subtype.
    Journal
    |
    HER-2 (Human epidermal growth factor receptor 2) • AR (Androgen receptor) • IFIT3 (Interferon Induced Protein With Tetratricopeptide Repeats 3) • TM4SF1 (Transmembrane 4 L Six Family Member 1)
    |
    HER-2 overexpression • HER-2 negative • AR positive • AR expression • TM4SF1 expression • TM4SF1 overexpression
    over3years
    HIF-1α-activated TM4SF1-AS1 promotes the proliferation, migration, and invasion of hepatocellular carcinoma cells by enhancing TM4SF1 expression. (PubMed, Biochem Biophys Res Commun)
    Finally, TM4SF1 prominently reversed the inhibitory role of TM4SF1-AS1 depletion in Hep3B cells. In summary, hypoxia-responsive TM4SF1-AS1 was overexpressed in human HCC and contributed to the malignant behaviors of tumor cells by enhancing TM4SF1-AS1 expression.
    Journal
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • EPAS1 (Endothelial PAS domain protein 1) • IFIT3 (Interferon Induced Protein With Tetratricopeptide Repeats 3) • TM4SF1 (Transmembrane 4 L Six Family Member 1)
    |
    TM4SF1 expression • TM4SF1 overexpression