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    BIOMARKER:

    TLR5 overexpression

    i
    Other names: TLR5, Toll Like Receptor 5, Toll/Interleukin-1 Receptor-Like Protein 3, Toll-Like Receptor 5, TIL3, Systemic Lupus Erythematosus Susceptibility 1, MGC126430, MGC126431, FLJ10052, MELIOS, SLEB1, SLE1
    Entrez ID:
    7100
    over2years
    Upregulation of TLR5 indicates a favorable prognosis in prostate cancer. (PubMed, Prostate)
    TLR5, as an innate immunity receptor, is a functional TLR in human prostate cancer epithelial cells. TLR5 plays an important role in prostate cancer development and is a new potential prognosis biomarker. TLR5 may represent a novel immunotherapy target against prostate cancer.
    Journal • IO biomarker
    |
    TLR5 (Toll Like Receptor 5)
    |
    TLR5 overexpression
    over3years
    TLR5 Variants Are Associated with the Risk for COPD and NSCLC Development, Better Overall Survival of the NSCLC Patients and Increased Chemosensitivity in the H1299 Cell Line. (PubMed, Biomedicines)
    Finally, genome-wide transcriptomic analysis on WI-38 and H1299 cells overexpressing TLR5 or TLR5, respectively, indicated the existence of different transcription profiles affecting several cellular pathways potentially associated with a dysregulated immune response. Our results suggest that TLR5 could be recognized as a potential biomarker for COPD and LC development with functional relevance.
    Preclinical • Journal • IO biomarker
    |
    TLR5 (Toll Like Receptor 5)
    |
    MAPK1 overexpression • TLR5 overexpression
    over4years
    The Relationship between the Tissue Expression of TLR2, TLR4, TLR5, and TLR7 and Systemic Inflammatory Responses in Colorectal Cancer Patients. (PubMed, Oncology)
    High tissue TLR2, TLR5, and TLR7 levels were associated with a better prognosis. Among low-CRP patients, those with high TLR2, TLR5, and TLR7 immunoexpressions exhibited a better prognosis. Among high CRP patients, a high TLR4 immunoexpression was associated with a better prognosis.
    Clinical • Journal • IO biomarker
    |
    TLR4 (Toll Like Receptor 4) • TLR5 (Toll Like Receptor 5) • TLR7 (Toll Like Receptor 7) • CRP (C-reactive protein)
    |
    TLR5 overexpression