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    BIOMARKER:

    TLR4-L

    i
    Other names: TLR4, Toll Like Receptor 4, Toll-Like Receptor 4, HToll, Toll Like Receptor 4 Protein, Homolog Of Drosophila Toll, CD284 Antigen, ARMD10, CD284, TLR-4, TOLL
    Entrez ID:
    7099
    Related biomarkers:
    Expression
    Mutation
    almost3years
    PAUF induces migration of human pancreatic cancer cells exclusively via the TLR4/MyD88/NF-κB signaling pathway (AACR 2023)
    In conclusion, for the first time this study demonstrates that TLR4 expressed on PC cell surfaces functions as a receptor of PAUF to mediate its metastasis-promoting effects, which are exclusively through the MyD88/NF-κB signaling pathway. This study also suggests TLR4 as a potential biomarker for identification of optimal patients, and a new therapeutic target to treat PC. Anti-PAUF antibody used in this study is currently evaluated by clinical trials in France, Spain, and US FDA.
    IO biomarker
    |
    MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • TLR4 (Toll Like Receptor 4) • ZG16B (Zymogen Granule Protein 16B)
    |
    TLR4 overexpression • TLR4-L
    over3years
    TLR2 and TLR4 in colorectal cancer: relationship to tumor necrosis and markers of systemic inflammation. (PubMed, Neoplasma)
    These findings indicate that tumor necrosis is associated with low TLR4 expression in cancer cells and that low TLR4 expression correlates with a strong systemic inflammatory response. The low TLR2 expression in normal mucosa and its association with systemic inflammation suggest that the normal mucosa may reflect or contribute to the systemic inflammatory response.
    Journal • IO biomarker
    |
    IL6 (Interleukin 6) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • TLR4 (Toll Like Receptor 4) • CRP (C-reactive protein) • TLR2 (Toll Like Receptor 2)
    |
    TLR4-L
    over4years
    Immunohistochemical Analysis of Inflammasome Signaling Component Expression Among Patients with Low Risk and High Risk Myelodysplastic Syndrome Using Tissue Microarray (ASH 2021)
    IHC staining of inflammasome activators using TMA may allow better characterization of molecular pathways contributing the MDS pathogenesis. A correlation was seen between expression of antigens known to be increased downstream of NLRP3 inflammasome activation. Survival was increased in patients with low CPLA2 expression, high beta-catenin expression, and low TLR4 expression.
    Clinical
    |
    CD33 (CD33 Molecule) • S100A9 (S100 Calcium Binding Protein A9) • TLR4 (Toll Like Receptor 4) • IL1B (Interleukin 1, beta) • NLRP3 (NLR Family Pyrin Domain Containing 3)
    |
    CTNNB1 expression • S100A9 expression • TLR4-L