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    BIOMARKER:

    TLR3 overexpression

    i
    Other names: Toll Like Receptor 3, Toll-Like Receptor 3, CD283, CD283 Antigen, IIAE2, TLR3
    Entrez ID:
    7098
    9ms
    RNA is a pro-apoptotic target of cisplatin in cancer cell lines and C. elegans. (PubMed, Biomed Pharmacother)
    TLR3 inhibition reduced the pro-apoptotic effects of Pt-RNA and cisplatin, but not of paclitaxel (off-target control). Gene expression analysis showed that Pt-RNA (but not RNA) significantly enhanced the mRNA levels of nuclear factor kappa B subunit 2 and interleukin-8 in HepG2 cells, suggesting that Pt-RNA is a damage-associated molecular pattern that additionally causes pro-inflammatory responses. Together, this data suggests that not only DNA but also cellular RNA is a functionally relevant target of cisplatin, leading to pro-apoptotic and immunogenic effects.
    Preclinical • Journal • IO biomarker
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    CASP3 (Caspase 3) • TLR3 (Toll Like Receptor 3) • CASP7 (Caspase 7) • NFKB2 (Nuclear Factor Kappa B Subunit 2)
    |
    TLR3 overexpression
    |
    cisplatin • paclitaxel
    1year
    The Functional Mechanisms of Toll-Like Receptor 3 and Its Implications in Digestive System Tumors. (PubMed, Front Biosci (Landmark Ed))
    This has provided new ideas and hopes for the treatment of digestive system tumors. This review discusses the mechanisms of TLR3 and its frontier research in digestive system tumors.
    Review • Journal • IO biomarker
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    TLR3 (Toll Like Receptor 3)
    |
    TLR3 overexpression