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    GENE:

    TLE4 (TLE Family Member 4 Transcriptional Corepressor)

    i
    Other names: TLE4, TLE Family Member 4 Transcriptional Corepressor, GRG4, E(Spl), ESG, Transducin-Like Enhancer Of Split 4 (E(Sp1) Homolog, Drosophila), Transducin Like Enhancer Of Split 4, Transducin-Like Enhancer Protein 4, Groucho-Related Protein 4, Grg-4, Transducin-Like Enhancer Of Split 4 Homolog Of Drosophila E(Sp1), Enhancer Of Split Groucho 4, B Lymphocyte Gene 1, KIAA1261, E(SpI), BCE-1, BCE1, ESG4
    Associations

    News

    Trials
    2ms
    Subtype-Independent Dysregulation of the Notch Signaling Pathway and Its miRNA Regulators in Breast Cancer. (PubMed, Biomedicines)
    The consistent alterations suggest the presence of a shared Notch-driven oncogenic signature in breast cancer, potentially driving cell proliferation, stemness, and resistance to therapy. These findings enhance our understanding of Notch signaling in breast cancer and propose novel miRNA-Notch interactions as candidate targets for therapeutic intervention.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2) • MIR155 (MicroRNA 155) • NOTCH4 (Notch 4) • APH1A (Aph-1 Homolog A, Gamma-Secretase Subunit) • CTBP1 (C-Terminal Binding Protein 1) • MIR381 (MicroRNA 381) • TLE2 (TLE Family Member 2, Transcriptional Corepressor) • HEY1 (Hes Related Family BHLH Transcription Factor With YRPW Motif 1) • MIR145 (MicroRNA 145) • MIR98 (MicroRNA 98) • TLE4 (TLE Family Member 4 Transcriptional Corepressor)
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    HER-2 positive • HER-2 negative
    6ms
    Long noncoding RNA HNF4A-AS1 upregulates TLE4 to inhibit hepatitis B virus replication. (PubMed, Virus Res)
    The TLE4 WD-repeat domain is required for TLE4-mediated anti-HBV activity. Collectively, our findings have uncovered a negative feedback mechanism underlying HBV replication and HNF4A-AS1 expression and identify HNF4A-AS1 as a novel host restriction factor in HBV replication, providing a potential therapeutic target for HBV treatment.
    Journal
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    HNF1A (HNF1 Homeobox A) • TLE4 (TLE Family Member 4 Transcriptional Corepressor)
    9ms
    Development of a prognostic model for chemotherapy response and identification of TNFAIP2 as a target in colorectal cancer. (PubMed, Sci Rep)
    The oxaliplatin resistance-related gene signature (ORGSig) serves as a promising tool for predicting treatment response and prognosis in CRC patients receiving oxaliplatin-based chemotherapy. This signature also offers potential for guiding personalized therapy and overcoming drug resistance in clinical practice.
    Journal
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    TLE4 (TLE Family Member 4 Transcriptional Corepressor)
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    oxaliplatin
    9ms
    Helicobacter pylori induced miR-362-5p upregulation drives gastric cancer progression and links hepatocellular carcinoma through an exosome-dependent pathway. (PubMed, Front Cell Infect Microbiol)
    pylori infection upregulates miR-362-5p, facilitating GC progression via TLE4 targeting. Exosome-mediated transfer amplifies its effects, contributing to liver damage and potentially facilitating HCC.
    Journal
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    TLE4 (TLE Family Member 4 Transcriptional Corepressor)
    1year
    TLE4 is a repressor of the oncogenic activity of TLX3 in T-cell acute lymphoblastic leukemia. (PubMed, Leukemia)
    Furthermore, TLE4 showed to have a repressive effect on ex vivo TLX3 T-ALL cell growth, likely caused by a partial reversal of the TLX3 transcriptional profile. In conclusion, we developed a TLX3+FLT3-ITD pro-T cell model and used it to illustrate that TLX3 directly represses TLE4 expression, which is beneficial for the oncogenic function of TLX3.
    Journal
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    FLT3 (Fms-related tyrosine kinase 3) • IL7 (Interleukin 7) • TLE4 (TLE Family Member 4 Transcriptional Corepressor)
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    FLT3-ITD mutation • FLT3 mutation
    over1year
    Epigenetic and oncogenic inhibitors cooperatively drive differentiation and kill KRAS-mutant colorectal cancers. (PubMed, Cancer Discov)
    Accordingly, cell death can be prevented by activating β-catenin, blocking differentiation, or by ablating BMF expression. Collectively, these studies reveal a new therapeutic approach for treating KRAS-mutant CRCs and illustrate a critical convergence of EZH2 and RAS on oncogenic WNT signals, intestinal differentiation, and apoptosis.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • BMF (Bcl2 Modifying Factor) • TLE4 (TLE Family Member 4 Transcriptional Corepressor)
    over1year
    TLE4 downregulation identified by WGCNA and machine learning algorithm promotes papillary thyroid carcinoma progression via activating JAK/STAT pathway. (PubMed, J Cancer)
    This study sheds light on TLE4's crucial role in PTC pathogenesis, positioning it as a potential biomarker and target for therapy. The integration of multi-omics data and advanced analytical methods provides a robust framework for understanding PTC at a molecular level, potentially guiding personalized treatment strategies.
    Journal • Machine learning
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    TLE4 (TLE Family Member 4 Transcriptional Corepressor)
    almost2years
    Exome sequencing identifies ADGRG4 G-protein-coupled receptors gene as a novel cancer biomarker in ovarian cancer patients from North India. (PubMed, J Biochem Mol Toxicol)
    When corrected for age and BMI, the dominating OR of variant rs5930932 was 1.035 (1.003-1.069) under HWE patients (0.95) and controls (0.18), with a p-value of (0.03). According to the findings of the current investigation, the ADGRG4 gene variant rs5930932 increases the chance of developing ovarian cancer in the studied population.
    Journal
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    TLE4 (TLE Family Member 4 Transcriptional Corepressor)
    2years
    Analyzing aberrant DNA methylation in colorectal cancer uncovered intangible heterogeneity of gene effects in the survival time of patients. (PubMed, Sci Rep)
    The relationship between identified DMGs/hub genes and patient survival time uncovered a two-component mixture of AFT regression model. The genes NMNAT2, ZFP42, NPAS2, MYLK3, NUDT13, KIRREL3, and FKBP6 and hub genes SOST, NFATC1, and TLE4 were associated with survival time in the most aggressive form of the disease that can serve as potential diagnostic targets for early CRC detection.
    Journal • IO biomarker • Epigenetic controller
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    CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • SEMA7A (Semaphorin 7A) • NFATC1 (Nuclear Factor Of Activated T Cells 1) • TLE4 (TLE Family Member 4 Transcriptional Corepressor)
    over3years
    Association of the Timeless Gene with Prognosis and Clinical Characteristics of Human Lung Cancer. (PubMed, Diagnostics (Basel))
    Of note, overexpression of the Timeless gene increased the expression level of ESPL1 at both the mRNA and protein levels. (4) The present study explored the clinical significance of the Timeless gene and its correlated gene ESPL1 in patients with lung cancer, thereby providing a potential therapeutic target for lung cancer.
    Journal
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    TIMELESS (Timeless Circadian Regulator) • TLE4 (TLE Family Member 4 Transcriptional Corepressor)
    over3years
    DNA Methylation Profile in CpG-depleted Regions Uncovers a High-Risk Subtype of Early-stage Colorectal Cancer. (PubMed, J Natl Cancer Inst)
    We demonstrated the prognostic significance of DNA methylation profile in CpG-depleted region, which may serve as a valuable source for tumor biomarkers. MePEC could identify an epigenetic subtype with high risk of recurrence and improve the prognostic accuracy of current clinical variables in early-stage CRC.
    Journal • Epigenetic controller
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    FAT3 (FAT Atypical Cadherin 3) • TLE4 (TLE Family Member 4 Transcriptional Corepressor)