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    BIOMARKER:

    TLE3 expression

    i
    Other names: TLE3, TLE Family Member 3, Transcriptional Corepressor, ESG3, Transducin-Like Enhancer Of Split 3 (E(Sp1) Homolog, Drosophila), Enhancer Of Split Groucho-Like Protein 3, Transducin Like Enhancer Of Split 3, Transducin-Like Enhancer Protein 3, GRG3, Transducin-Like Enhancer Of Split 3, Homolog Of Drosophila E(Sp1), Transducin-Like Enhancer Of Split 3 Short Isoform, Enhancer Of Split Groucho 3
    Entrez ID:
    7090
    over1year
    HHEX suppresses advanced thyroid cancer by interacting with TLE3. (PubMed, Mol Cell Endocrinol)
    Nuclear localized HHEX bound to and upregulated TLE3 expression by preventing TLE3 protein from being distributed to the cytoplasm and being ubiquitinated. In conclusion, our study suggested that restoring HHEX expression has the potential to be a new strategy in the treatment of advanced thyroid cancer.
    Journal • Metastases
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    TLE3 (TLE Family Member 3, Transcriptional Corepressor)
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    TLE3 expression
    over1year
    TLE3-AKR1B1 signaling axis participating in the malignant progression of gastrointestinal stromal tumor by regulating galactose metabolism (ESMO-GI 2023)
    This study shows that TLE3-AKR1B1 signaling axis can participate in GIST malignant progression through regulation of galactose metabolism, providing experimental data for understanding the mechanism of GIST malignant progression from the perspective of metabolic reprogramming, and also providing a new target for GIST treatment.
    Stroma
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    PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • TLE3 (TLE Family Member 3, Transcriptional Corepressor)
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    PDGFRA mutation • TLE3 expression
    over1year
    TLE3 Sustains Luminal Breast Cancer Lineage Fidelity to Suppress Metastasis. (PubMed, Cancer Res)
    These results establish TLE3 as an essential transcriptional repressor that sustains the more differentiated and less metastatic nature of luminal breast cancers. Approaches to induce TLE3 expression could promote the acquisition of less aggressive, more treatable disease states to extend patient survival.
    Journal
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    ER (Estrogen receptor) • FOXA1 (Forkhead Box A1) • SOX9 (SRY-Box Transcription Factor 9) • TGFB1 (Transforming Growth Factor Beta 1) • TLE3 (TLE Family Member 3, Transcriptional Corepressor) • TGFB2 (Transforming Growth Factor Beta 2)
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    TLE3 expression
    over2years
    Ginsenoside Rg3 induces apoptosis and inhibits proliferation by down-regulating TIGAR in rats with gastric precancerous lesions. (PubMed, BMC Complement Med Ther)
    Grg3 can induce apoptosis and inhibit cell proliferation in MNNG-induced GPL rats. The mechanism may be related to down-regulating the expression levels of TIGAR and production levels of GSH, NADP and G6PD, and up-regulating the concentration of ROS.
    Preclinical • Journal
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    TLE3 (TLE Family Member 3, Transcriptional Corepressor)
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    TLE3 expression
    3years
    Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia. (PubMed, Cell Rep)
    Furthermore, it triggers genome-wide redistribution of RUNX1, TLE3, and HDAC1 from enhancers to promoters, leading to repression of self-renewal genes, including MYC and MYB. Our studies highlight RUNX1 and CEBPA transcription factor swapping as a feature of leukemia cell differentiation and reveal that FOXC1 prevents this by stabilizing enhancer binding of a RUNX1/HDAC1/TLE3 transcription repressor complex to oncogenic effect.
    Journal
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    RUNX1 (RUNX Family Transcription Factor 1) • CEBPA (CCAAT Enhancer Binding Protein Alpha) • HDAC1 (Histone Deacetylase 1) • TLE3 (TLE Family Member 3, Transcriptional Corepressor) • FOXC1 (Forkhead Box C1)
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    TLE3 expression • FOXC1 expression