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    GENE:

    TLE2 (TLE Family Member 2, Transcriptional Corepressor)

    i
    Other names: TLE2, TLE Family Member 2, Transcriptional Corepressor, ESG2, Transducin-Like Enhancer Of Split 2 (E(Sp1) Homolog, Drosophila), Enhancer Of Split Groucho-Like Protein 2, Transducin Like Enhancer Of Split 2, Transducin-Like Enhancer Protein 2, GRG2, Transducin-Like Enhancer Of Split 2, Homolog Of Drosophila E(Sp1), Enhancer Of Split Groucho 2
    2ms
    Subtype-Independent Dysregulation of the Notch Signaling Pathway and Its miRNA Regulators in Breast Cancer. (PubMed, Biomedicines)
    The consistent alterations suggest the presence of a shared Notch-driven oncogenic signature in breast cancer, potentially driving cell proliferation, stemness, and resistance to therapy. These findings enhance our understanding of Notch signaling in breast cancer and propose novel miRNA-Notch interactions as candidate targets for therapeutic intervention.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2) • MIR155 (MicroRNA 155) • NOTCH4 (Notch 4) • APH1A (Aph-1 Homolog A, Gamma-Secretase Subunit) • CTBP1 (C-Terminal Binding Protein 1) • MIR381 (MicroRNA 381) • TLE2 (TLE Family Member 2, Transcriptional Corepressor) • HEY1 (Hes Related Family BHLH Transcription Factor With YRPW Motif 1) • MIR145 (MicroRNA 145) • MIR98 (MicroRNA 98) • TLE4 (TLE Family Member 4 Transcriptional Corepressor)
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    HER-2 positive • HER-2 negative
    5ms
    RNA binding protein DDX3X drives pancreatic cancer progression via the TLE2-MYL9 axis. (PubMed, Sci Adv)
    Targeting the DDX3X-TLE2-MYL9 pathway considerably reduces PDAC progression. This research reveals a promising approach for treating PDAC by focusing on biomechanical cues.
    Journal
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    KLF4 (Kruppel-like factor 4) • TLE2 (TLE Family Member 2, Transcriptional Corepressor) • DDX3X (DEAD-Box Helicase 3 X-Linked) • TCF4 (Transcription Factor 4)
    2years
    Thalamic Structural Connectivity Alterations in Patients with Temporal Lobe Epilepsy (AES 2023)
    Here we identified the bilateral and widespread aberrant structural connections of the thalamus in TLE which may contribute to seizure generation and spread. These findings may contribute to understanding the thalamus’s role in TLE, potentially leading to improved epilepsy treatment.
    Clinical
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    TLE2 (TLE Family Member 2, Transcriptional Corepressor)
    almost4years
    Novel necroptosis-related gene signature for predicting the prognosis of pancreatic adenocarcinoma. (PubMed, Aging (Albany NY))
    Moreover, CASKIN2, TLE2, USP20, SPRN, ARSG, MIR106B, and MIR98 might be associated with low-risk patients with PAAD. NRGs and the relationship of the immune function, immune checkpoints, and m6A gene expression with NRGs in PAAD may be considered as potential therapeutic targets that should be further studied.
    Journal • Gene Signature
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    TLE2 (TLE Family Member 2, Transcriptional Corepressor) • MIR106B (MicroRNA 106b) • MIR98 (MicroRNA 98)
    over4years
    The prognostic role of the Transducin-like Enhancer of split protein family in lung adenocarcinoma. (PubMed, Transl Lung Cancer Res)
    Moreover, the combined expression of these two proteins was a good tool for prognostication. High TLE1 expression and low TLE2 are independent adverse prognostic factors in LUAD and can serve as prognostic biomarkers.
    Journal
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    TLE2 (TLE Family Member 2, Transcriptional Corepressor)
    almost5years
    A Risk Signature with Nine Stemness Index-Associated Genes for Predicting Survival of Patients with Uterine Corpus Endometrial Carcinoma. (PubMed, J Oncol)
    Endometrial cancer cell stemness is related to patient prognosis. The nine-gene risk signature is an independent prognostic factor and can accurately predict endometrial cancer patient prognosis.
    Clinical • Journal
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    TLE2 (TLE Family Member 2, Transcriptional Corepressor)