^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    TK1 elevation

    i
    Other names: TK1, Thymidine Kinase 1, Thymidine Kinase Cytosolic, Cytosolic Thymidine Kinase, Epididymis Secretory Sperm Binding Protein, Thymidine Kinase 1 Soluble Isoform, Thymidine Kinase 1 Soluble, TK2
    Entrez ID:
    7083
    Related biomarkers:
    Expression
    12ms
    TK1 expression influences pathogenicity by cell cycle progression, cellular migration, and cellular survival in HCC 1806 breast cancer cells. (PubMed, PLoS One)
    Creation of a protein-protein interaction map of TK1 and the pathogenic factors we evaluated predict that the majority of factors evaluated either directly or indirectly interact with TK1. Our findings argue that TK1 elevation directly increases HCC 1806 cell pathogenicity and is likely occurring by p21- and AKT3-mediated mechanisms to promote cell cycle arrest, cellular migration, and cellular survival.
    Journal
    |
    TK1 (Thymidine Kinase 1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)
    |
    TK1 elevation • TK1 expression
    1year
    Thymidine kinase 1 as a target is regulated by the hsa-let-7b-5p/LINC00665 axis and affects NSCLC prognosis. (PubMed, Heliyon)
    When the regulatory network of LINC00665/has-let-7b-5p/TK1 was assessed, it was observed that elevated TK1 levels may affect the prognosis of NSCLC. Therefore, it could be considered a prognostic biomarker and a probable therapeutic target for predicting NSCLC prognosis.
    Journal
    |
    TK1 (Thymidine Kinase 1) • LINC00665 (Long Intergenic Non-Protein Coding RNA 665) • MIRLET7B (MicroRNA Let-7b)
    |
    TK1 elevation • TK1 expression