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tipapkinogene sovacivec (TG4001)
i
Other names: MVA-HPV-IL2, TG-4001, TG4001, RG3484, RO5217790, MVA virus vector encoding HPV types 16 E6 and E7 antigens and IL-2 adjuvant
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Company:
European Organization for Research and Treatment of Cancer, Transgene
Drug class:
IL-2 stimulant, HPV-16 E6 protein inhibitor, HPV-16 E7 protein inhibitor
Related drugs:
1m
Phase Ib/II of TG4001 and Avelumab in HPV16 Positive R/M Cancers (clinicaltrials.gov)
P1/2, N=150, Active, not recruiting, Transgene | Recruiting --> Active, not recruiting | Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Dec 2023 --> Dec 2024
Enrollment closed • Trial completion date • Trial primary completion date • Metastases
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Bavencio (avelumab) • tipapkinogene sovacivec (TG4001)
9ms
Phase Ib/II trial of tipapkinogene sovacivec, a therapeutic human papillomavirus16-vaccine, in combination with avelumab in patients with advanced human papillomavirus16-positive cancers. (PubMed, Eur J Cancer)
TG4001 in combination with avelumab is safe, demonstrated antitumour activity in heavily pre-treated HPV16+ cancer patients, and is currently being evaluated in a randomised phase II trial in patients with incurable anogenital cancer and limited hepatic involvement.
Clinical • P1/2 data • Clinical Trial,Phase II • Journal • Combination therapy • Metastases
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IFNG (Interferon, gamma) • IL2 (Interleukin 2)
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Bavencio (avelumab) • tipapkinogene sovacivec (TG4001)
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