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    BIOMARKER:

    TINCR overexpression

    i
    Other names: TINCR, TINCR Ubiquitin Domain Containing, NCRNA00036, LINC00036, Onco-LncRNA-16, PLAC2, Tissue Differentiation-Inducing Non-Protein Coding RNA, Long Intergenic Non-Protein Coding RNA 36, Placenta-Specific 2 (Non-Protein Coding), Terminal Differentiation-Induced NcRNA, FLJ90734, Terminal Differentiation-Induced Cornification Regulator, Ubiquitin Domain-Containing Protein TINCR, Placenta-Specific Protein 2, Non-Protein Coding RNA 36, Placenta-Specific 2, NONHSAG024566.2, HSALNG0123468, HSALNG0123467, Lnc-TINCR-1
    Entrez ID:
    257000
    almost2years
    Long non-coding RNA TINCR suppresses growth and epithelial-mesenchymal transition by inhibiting Wnt/β-catenin signaling pathway in human pancreatic cancer PANC-1 cells: Insights from in vitro and in vivo studies. (PubMed, Acta Pharm)
    This study sheds light on the tumour-suppressive role of TINCR in PANC-1 cells and suggests its potential as a therapeutic target. These results shed light on the molecular mechanisms underlying the impact of TINCR on pancreatic cancer and offer promising opportunities for innovative therapeutic strategies to improve outcomes in this serious malignancy.
    Preclinical • Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • BAX (BCL2-associated X protein) • TINCR (TINCR Ubiquitin Domain Containing)
    |
    BCL2 expression • TINCR overexpression
    over3years
    lncRNA TINCR Regulates Proliferation and Invasion of Hepatocellular Carcinoma Cells by Regulating the miR-375/ATG7 Axis. (PubMed, J Oncol)
    By controlling the miR-375/ATG7 axis, the lncRNA TINCR impacts the proliferation and invasion of liver cancer cells. Therefore, the lncRNA TINCR/miR-375/ATG7 signaling axis could be a novel biological target for the diagnosis and therapy of liver cancer.
    Journal
    |
    MIR375 (MicroRNA 375) • TINCR (TINCR Ubiquitin Domain Containing) • ATG7 (Autophagy Related 7)
    |
    TINCR overexpression
    over3years
    IncRNA PLAC2 Upregulates CDK6 by Directly Targeting miR-29C to Promote Cell Proliferation in Lung Squamous Cell Carcinoma. (PubMed, Crit Rev Eukaryot Gene Expr)
    Moreover, overexpression of miR-29C suppressed the role of overexpression of PLAC2 in cell proliferation and cell cycle progression. In conclusion, PLAC2 upregulates CDK6 by downregulating miR-29C to promote LSCC cell proliferation.
    Journal
    |
    CDK6 (Cyclin-dependent kinase 6) • TINCR (TINCR Ubiquitin Domain Containing)
    |
    CDK6 overexpression • TINCR overexpression • CDK6 expression
    almost4years
    Long non-coding RNA placenta‑specific protein 2 regulates the chemosensitivity of cancer cells to cisplatin in hepatocellular carcinoma (HCC) by sponging microRNA-96 to upregulate X-linked inhibitor of apoptosis protein. (PubMed, Bioengineered)
    LncRNA PLAC2 and miR-96 directly interacted with each other, while they failed to regulate the expression of each other. In conclusion, lncRNA PLAC2 negatively regulates the chemosensitivity of HCC cells to cisplatin, possibly by sponging miR-96 to upregulate miR-96.
    Journal
    |
    MIR96 (MicroRNA 96) • XIAP (X-Linked Inhibitor Of Apoptosis) • TINCR (TINCR Ubiquitin Domain Containing)
    |
    XIAP overexpression • TINCR overexpression
    |
    cisplatin
    almost4years
    Long noncoding RNA TINCR facilitates hepatocellular carcinoma progression and dampens chemosensitivity to oxaliplatin by regulating the miR-195-3p/ST6GAL1/NF-κB pathway. (PubMed, J Exp Clin Cancer Res)
    Our finding indicated that there existed a TINCR/miR-195-3p/ST6GAL1/NF-κB signaling regulatory axis that regulated tumor progression and oxaliplatin resistance, which might be exploited for anticancer therapy in HCC.
    Journal
    |
    ST6GAL1 (ST6 Beta-Galactoside Alpha-2,6-Sialyltransferase 1) • TINCR (TINCR Ubiquitin Domain Containing) • MIR195 (MicroRNA 195)
    |
    TINCR overexpression
    |
    oxaliplatin