TIMM17A (Translocase Of Inner Mitochondrial Membrane 17A)

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4ms

Elevated co-expression of TIMM17A and NMT1 is associated with poor survival in non-small cell lung cancer. (PubMed, Sci Rep)

This highlights a novel NMT1/TIMM17A axis as a promising pathway for predicting patient prognosis. Further studies are warranted investigating both genes as targets for novel therapeutic strategies for KRAS mutant non-small cell lung carcinoma with STK11 and/or KEAP1 co-mutations.

4 months ago

Journal

KRAS (KRAS proto-oncogene GTPase) • STK11 (Serine/threonine kinase 11) • KEAP1 (Kelch Like ECH Associated Protein 1) • TIMM17A (Translocase Of Inner Mitochondrial Membrane 17A)

KRAS mutation • STK11 mutation • KEAP1 mutation

9ms

HSF1 remodels mitochondrial biogenesis and function in cancer cells via TIMM17A. (PubMed, bioRxiv)

The HSF1- HSPD1/HSPE1-TIMM17A axis remodels the mitochondrial proteome to promote mitochondrial translation and energy production, thereby supporting robust cell proliferation. Our work reveals a mechanism by which mitochondria adjust protein uptake according to the folding capacity in the matrix by altering TIM complex composition.

9 months ago

Journal

HSF1 (Heat Shock Transcription Factor 1) • HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1) • TIMM17A (Translocase Of Inner Mitochondrial Membrane 17A)

10ms

MicroRNA-593-3p Inhibits Growth and Metastasis of Human Breast Cancer Cells by Regulating TIMM17A Expression. (PubMed, Biochem Genet)

Transwell assays further demonstrated that miR-593-3p reduced the invasive potential of MDA-MB-231 cells by regulating TIMM17A These findings indicate that miR-593-3p functions as a tumor suppressor by targeting TIMM17A, influencing both proliferative and invasive properties of breast cancer cells. The identification of this regulatory axis suggests that miR-593-3p could serve as a promising therapeutic target for breast cancer treatment.

10 months ago

Journal

ANXA5 (Annexin A5) • TIMM17A (Translocase Of Inner Mitochondrial Membrane 17A)

10ms

Myricetin ameliorates the effects of hydrogen peroxide-induced oxidative stress in human mesenchymal stem cells: an ultrastructural and immunocytochemical study. (PubMed, Ultrastruct Pathol)

The results suggest that myricetin prevents oxidative stress-induced apoptosis and inflammation in the HUC-MSCs. Myricetin can be combined with HUC-MSCs in cell culture and considered as a supportive alternative treatment option.

10 months ago

Journal

TNFA (Tumor Necrosis Factor-Alpha) • CASP3 (Caspase 3) • TIMM17A (Translocase Of Inner Mitochondrial Membrane 17A)

11ms

Sulforaphane downregulates mitochondrial TIGAR via inhibiting mitochondrial transmembrane assembly and LONP1/CASP3 axis causing apoptosis. (PubMed, Biochem Biophys Res Commun)

Further, SFN downregulated mitoprotease LONP1 and decreased the binding of LONP1 to TIGAR; knockdown of LONP1 activated mitochondrial caspase-3 causing the cleavage of mitochondrial TIGAR; SFN-mediated the reduction of TIGAR decreased NADPH leading to ROS elevation and apoptosis in NSCLC. These studies will provide key targets for anti-NSCLC therapy.

11 months ago

Journal

CASP3 (Caspase 3) • TIGAR (TP53 Induced Glycolysis Regulatory Phosphatase) • TIMM17A (Translocase Of Inner Mitochondrial Membrane 17A)

1year

OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase. (PubMed, Cell Rep)

The expression of OCIAD1 was in turn regulated by the status of the TIM23 complex. We postulate that OCIAD1 together with prohibitins constitute a regulatory axis that differentially regulates variants of human TIM23.

1 year ago

Journal

TIMM17A (Translocase Of Inner Mitochondrial Membrane 17A)

over1year

N-Myristoyltransferase Inhibition causes Mitochondrial Iron Overload and Parthanatos in TIM17A-dependent Aggressive Lung Carcinoma. (PubMed, Cancer Res Commun)

This study reveals the unexpected connection between protein myristoylation, the mitochondrial import machinery, and iron homeostasis. It also uncovers myristoylation inhibitors as novel inducers of parthanatos in cancer, and the novel axis N-myristoyltransferase-TIM17A as a potential therapeutic target in highly aggressive lung carcinomas.

over 1 year ago

Journal

KRAS (KRAS proto-oncogene GTPase) • STK11 (Serine/threonine kinase 11) • KEAP1 (Kelch Like ECH Associated Protein 1) • TIMM17A (Translocase Of Inner Mitochondrial Membrane 17A)

almost2years

TIMM17A overexpression in lung adenocarcinoma and its association with prognosis. (PubMed, Sci Rep)

Knockdown of TIMM17A inhibited the growth of LUAD cells. The potential of TIMM17A as a biomarker and therapeutic target for LUAD presents a promising pathway for improving patient diagnosis and treatment strategies.

almost 2 years ago

Journal

TIMM17A (Translocase Of Inner Mitochondrial Membrane 17A)

over2years

Invasive Breast Cancer: miR-24-2 Targets Genes Associated with Survival and Sensitizes MDA-MB-231 Cells to Berberine. (PubMed, OMICS)

In all, this study reports on the novel target genes of miR-24-2 in invasive breast cancer/TNBC, and that miR-24-2 sensitizes MDA-MB-231 cells to berberine. These data lend evidence for the translational potentials of miR-24-2 for invasive breast cancer diagnostic and therapeutic innovation.

over 2 years ago

Journal • BRCA Biomarker

BRCA (Breast cancer early onset) • HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1) • IL1R1 (Interleukin 1 receptor, type I) • L1CAM (L1 cell adhesion molecule) • MIR24-2 (MicroRNA 24-2) • RACGAP1 (Rac GTPase activating protein 1) • SOD2 (Superoxide Dismutase 2) • DTX4 (Deltex E3 Ubiquitin Ligase 4) • HLA-DQB2 (Major Histocompatibility Complex, Class II, DQ Beta 2) • LYRM7 (LYR Motif Containing 7) • SAP30L (SAP30 Like) • SLC1A3 (Solute Carrier Family 1 Member 3) • TIMM17A (Translocase Of Inner Mitochondrial Membrane 17A)