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DRUG:

CUG288

i
Other names: TILKine-2, CUG288
Associations
Trials
Company:
Cugene
Drug class:
IL-2 stimulant
Related drugs:
Associations
Trials
3years
TILKine-2: A novel best-in-class tumor infiltrating lymphocyte (TIL) targeting engineered IL-2 with superior pre-clinical efficacy and safety for immunotherapy of cancer. (SITC 2021)
Conclusions By targeting TILs, TILKine-2 demonstrated robust anti-tumor efficacy by preferentially inducing proliferation, expansion, and activation of intra-tumoral lymphocytes while reducing systemic toxicity and improving therapeutic window. In conclusion, TILKine-2 is a promising therapeutic agent for clinical development.
Preclinical • Tumor-Infiltrating Lymphocyte • IO biomarker
|
CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • IL2 (Interleukin 2) • GZMB (Granzyme B)
|
CD8 expression
|
CUG288