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BIOMARKER:
TIAM1 overexpression
i
Other names: TIAM1, TIAM Rac1 Associated GEF 1, T-Lymphoma Invasion And Metastasis-Inducing Protein 1, T Cell Lymphoma Invasion And Metastasis 1, Human T-Lymphoma Invasion And Metastasis Inducing TIAM1 Protein, T-Cell Lymphoma Invasion And Metastasis 1
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In vivo, nude mice bearing TIAM1 knockdown SH-SY5Y cells showed improved overall survival and tumor growth suppression. The results demonstrate that inhibition of Tiam1 expression is a potential strategy for targeted therapy in neuroblastoma.
1 month ago
Journal
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RAC1 (Rac Family Small GTPase 1) • TIAM1 (TIAM Rac1 Associated GEF 1)
Our findings demonstrate the critical role of Tiam1 in PC development and the miR-590-5p/Tiam1/SLC2A3 signaling pathway may serve as a target for new PC therapeutic strategies.
5 months ago
Journal
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RAC1 (Rac Family Small GTPase 1) • TIAM1 (TIAM Rac1 Associated GEF 1)
Finally, pericytes within calcified vessels demonstrated decreased TIAM1 expression in the diseased area compared to the healthy tissue. In summary, our results demonstrate that TIAM1 regulates the cellular morphology and differentiation potential of human pericytes, representing a molecular switch between osteogenic and adipogenic cell fates.
10 months ago
Journal
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RHOA (Ras homolog family member A) • TIAM1 (TIAM Rac1 Associated GEF 1)
In addition, in vivo evidences also showed that ALKBH5 suppressed thyroid cancer progression by decreasing the m6A level of TIAM1. Our findings suggested that ALKBH5 inhibited thyroid cancer progression by inducing ferroptosis through m6A-TIAM1-Nrf2/HO-1 axis, suggesting ALKBH5 might be a potential target molecule for the treatment and diagnosis of thyroid cancer.
Moreover, miR-21-5p was found to exacerbate the BC proliferative and aggressive by targeting Tiam1. Altogether, our study highlights the critical role of Tiam1 in BC development and the miR-21-5p/Tiam1/PFKL signaling pathway may serve as a target for new anti-BC therapeutic strategies.
almost 2 years ago
Journal
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MIR21 (MicroRNA 21) • RAC1 (Rac Family Small GTPase 1) • TIAM1 (TIAM Rac1 Associated GEF 1)
TIAM1 overexpression restored the proliferation and invasion of DNM3OS-depleted HCC cells. Our data delineate a mechanism by which MSCs accelerate HCC growth and metastasis through a DNM3OS/KDM6B/TIAM1 axis.
To sum up, miR-1271-5p inhibits proliferation, invasion and migration of OC cells by directly repressing TIAM1 to inactivate the Notch signaling pathway, which provides an alternative therapeutic candidate for the advancement of OC treatment.