TIA1 (TIA1 Cytotoxic Granule Associated RNA Binding Protein)

BCG-driven glycolytic suppression and CD8+ T cell activation track with the condensate-forming capacity of TIA1. TIA1 emerges as a prognostic biomarker and a potential therapeutic axis to improve intravesical immunotherapy in NMIBC.

TIA1 gene, stress granule (SG) marker, is tightly regulated by miR-33a/KDM5C/H3K4me3 axis and exosomal miR-33a diminishes the formation of stromal SGs in CAFs. Collectively, our study reveals tumour selectively secretes miR-33a-5p through EVs to remodel the stromal SG formation and gain survival possibility for cancer cells in tumour core region, highlighting a novel regulatory mechanism of iron and nutrient level on EV secretion and the function of polyamine metabolism in reshaping epigenetic profiles.

Although increased densities of reactive γδ T-cells or γδ T-cell phenotypes in neoplastic cells are observed in various benign and malignant dermatologic conditions, the literature on this phenomenon-particularly in SPTCL-remains scarce. Our case highlights the importance of recognizing an increased γδ T-cell population in SPTCL to prevent misdiagnosis as a more aggressive lymphoma such as primary cutaneous γδ T-cell lymphoma, underscoring the need for thorough clinicopathologic correlation.

Aquinnah has identified an orally bioavailable, brain penetrant compound that is able to strongly reduce tau pathology in a mouse model of tauopathy with late stage disease. These results show strong promise as a potential therapeutic agent for treatment of Alzheimer's disease and related disorders.

In conclusion, our findings demonstrated a lower rate of LEF1 expression in DUSP22-rearranged C-ALCL/LyP compared to previous reports that predominantly focused on S-ALCL. Moreover, we observed that the majority of ATLL cases also expressed LEF1, suggesting that the LEF1+/TIA1- immunoprofile does not differentiate DUSP22-rearranged C-ALCL/LyP from ATLL.

Our results show that MEITL is extremely rare, accounting for only 2.4% of all lymphomas involving the intestines. Patients with MEITL have a poor prognosis, with a median OS of less than six months. However, early elective surgery can significantly improve patient survival.

Punch biopsy of the right abdomen showed a fibrotic dermis and an interstitial infiltrate of small lymphocytes displaying nuclear hyperchromasia and irregular nuclear contours. An epidermotropic infiltrate of similar-appearing lymphocytes was found along the dermoepidermal junction. Immunohistochemistry was performed and demonstrated that lymphocytes express CD3, CD8, CD2, TCRβF1, and TIA1 and lack expression of CD7, TCRΔ, granzyme B, and CD56. CD68 and CD4 highlighted predominantly interstitial histiocytes. T-cell clonality studies demonstrated a clonal T-cell population. In conjunction with the clinical findings, a diagnosis of interstitial mycosis fungoides (IMF) was made. Given the unusual clinical findings without typical patches and plaques of conventional MF, knowledge of IMF is critical to prevent misdiagnosis of an inflammatory dermatosis.