Thyroid Gland Papillary Carcinoma

Our findings uncover a previously unrecognized link between mitochondrial metabolic reprogramming, immune evasion and LNM in PTC and establish MGST1 as a robust biomarker for metastatic risk stratification and a pivotal metabolic-immune regulator. Moreover, the target-specific activity of toxoflavin provides a rational therapeutic strategy for patients with high-risk PTC characterized by MGST1-driven mitochondrial reprogramming and immune evasion.

miR-335-5p inhibited the expression of nearly all analyzed genes in less-differentiated thyroid cell lines. Thus, miR-335-5p may be a viable therapeutic target to restore radioiodine avidity in BRAF-mutant metastatic thyroid cancer and enhance KI treatment redifferentiation.

This study identifies a malignant cell-intrinsic signature for predicting PTC prognosis. Validated by single-cell data, our findings suggest that targeting ion channels may represent a potential therapeutic strategy for modulating neuro-immune interactions in thyroid cancer, pending experimental validation.

METTL7B promotes glycolysis and malignant progression in PTC by stabilizing HIF-1α through USP28-mediated deubiquitination.

This study developed and validated an interpretable ML model capable of accurately predicting reoperation outcomes in patients with recurrent or persistent PTC. The model may assist clinicians in identifying high-risk individuals and tailoring personalized treatment strategies.

Except for hypertrophic scar, none had significant patient-reported side effects. EBRT is a feasible adjuvant treatment option for selected pediatric DTC patients with locally aggressive disease - gross extrathyroidal extension or unresectable disease.

TL-LGNPPA is a rare nasopharyngeal tumor with histological features similar to papillary thyroid carcinoma. An accurate diagnosis requires a comprehensive consideration of histological morphological assessment, immunohistochemical analysis and imaging examination.

MCM2 deficiency induces cell cycle arrest, DNA damage, and CIN, ultimately accelerating tumorigenesis through oncogenic pathway activation. These findings identify MCM2 as a low-frequency, moderately penetrant susceptibility gene for fPTC and underscore the clinical value of MCM2 testing in informing early detection, preventive management, and precision treatment strategies for familial papillary thyroid carcinoma.

Warthin-like variant of papillary thyroid carcinoma is a rare thyroid malignancy. Its unique morphology is helpful for diagnosis and differential diagnosis, and its prognosis is relatively good.

P=N/A, N=400, Not yet recruiting, Xijing Hospital

P=N/A, N=200, Completed, Minia University

POSTN expression is associated with tumor progression by regulating AKT/mTOR signaling, which further leads to apoptosis and autophagy. POSTN may also be considered a valuable target for therapeutic strategies in PTC.