Thyroid Gland Medullary Carcinoma

In such a situation, the possibility of coexistence of MTC and PTC should be highly suspected. A standardized surgical treatment plan should be selected, and during the pathological examination, standardized sampling and meticulous reading of the slides should be emphasized, combined with immunohistochemical detection, to reduce the risk of missed diagnosis, provide accurate pathological diagnosis, and thereby offer reliable basis for the formulation of postoperative treatment strategies and prognosis assessment.

Following 2 cycles of PRRT, minimal response was observed, and the lesions lost avidity. A subsequent 99mTc-FAPI scan demonstrated favorable uptake in the metastatic lesions, including a non-octreotide-avid hepatic lesion, suggesting the potential utility of FAPI-based radiopharmaceuticals for MTC management.

The Lapatinib-Bevacizumab combination produced the most potent inhibition of cell viability, comparable to high-dose monotherapy. These findings suggest that combining kinase inhibitors with Bevacizumab may enhance antitumor activity, allow the use of lower drug doses, and overcome resistance, representing a promising therapeutic strategy for medullary thyroid carcinoma that warrants further investigation in clinical settings.

An additional unique feature was an area demonstrating a "mixed" C-cell/thyroid follicular epithelial phenotype. In this review we review the possible etiologies of calcitonin-negative MTC, the possibility of a neoplastic sequential progression from ultimobranchial bodies to CCH/MMC to medullary thyroid carcinoma with the individual elements (UBB, CCH/MMC, MTC) demonstrated in this thyroid, and previous postulations that ultimobranchial bodies may be the source of some follicular thyroid cancers, medullary thyroid cancers, and mixed tumors of medullary and follicular epithelial types.

P2, N=50, Active, not recruiting, University of Alberta | Recruiting --> Active, not recruiting | Trial completion date: Jun 2025 --> Jun 2026

P=N/A, N=20, Active, not recruiting, City of Hope Medical Center | Trial completion date: Sep 2025 --> Aug 2026

P2, N=30, Active, not recruiting, M.D. Anderson Cancer Center | Trial completion date: Nov 2025 --> Nov 2027 | Trial primary completion date: Nov 2025 --> Nov 2027

The combination of selpercatinib and cemiplimab was possible, with no new safety signals observed.

The patient received postoperative radioactive iodine therapy and levothyroxine...The coexistence of PTC and MTC in separate thyroid lobes is a rare occurrence. Accurate cytological, histopathological, and immunohistochemical evaluations are essential for proper diagnosis and management.

While studies have not definitively proven a causal link between biologics and cancer, concerns remain regarding their potential association with an increased risk of certain malignancies. This report describes an observed temporal association in a patient with psoriasis who was treated with the interleukin-17A inhibitor secukinumab for four years and subsequently developed metastatic medullary thyroid cancer.

PRRT with [¹⁷⁷Lu]Lu-DOTA-TATE is a well-tolerated treatment option for selected patients with advanced MTC, including those receiving first-line therapy and those with low SSTR expression. In our limited cohort, bone metastases were associated with shorter PFS, and discordant imaging/biochemical responses are common. Functional imaging-guided selection and individualized response assessment are essential for optimal management.

Among all comparisons, only SSTR2A expression significantly differed between DTs and other tumours. In conclusion, Ki-67 and INSM1 identify patients with more aggressive MTC, while SSTR2A defines a favourable subgroup with complete remission.