Thyroid Gland Follicular Carcinoma

P2, N=2175, Active, not recruiting, ECOG-ACRIN Cancer Research Group | Trial primary completion date: Oct 2026 --> Oct 2027

In follicular thyroid tumors, increased RI and PI values are associated with enhanced microvessel maturation rather than microvessel density. These findings suggest that quantitative Doppler indices may reflect qualitative vascular properties and have potential as noninvasive imaging biomarkers for assessing vascular invasion.

P2, N=29, Completed, Massachusetts Eye and Ear Infirmary | Active, not recruiting --> Completed

P=N/A, N=142, Not yet recruiting, University of Michigan Rogel Cancer Center | Trial completion date: Aug 2029 --> Aug 2027 | Trial primary completion date: Aug 2029 --> Aug 2027

The patient received external beam radiotherapy and systemic therapy with lenvatinib; however, the disease progressed, and he died 16 months after the diagnosis of cavernous sinus metastasis. This case highlights the aggressive potential of FTC, the limitations of radioiodine imaging in dedifferentiated disease, and the poor prognosis associated with skull-base metastases despite multimodal therapy.

P=N/A, N=200, Completed, Minia University

Exploratory analysis in a limited TERT cohort (8 mutated vs 103 wild-type) identified prospective radiomics patterns associated with TERT promoter mutations, suggesting potential surrogate imaging biomarkers that warrant further investigation. Micro-CT radiomics shows promise as a complementary tool for diagnostic classification in thyroid cancer and offers a platform for quantitative 3D tissue characterization pending broader validation.

P=N/A, N=142, Not yet recruiting, University of Michigan Rogel Cancer Center | Trial completion date: Apr 2029 --> Aug 2029 | Initiation date: Apr 2026 --> Aug 2026 | Trial primary completion date: Apr 2029 --> Aug 2029

Despite I-131 treatment, she succumbed to death 6 months post-diagnosis. The index case highlights the utility of fine-needle aspiration cytology and the application of immunocytochemistry on cell blocks changing the norms for diagnosing carcinomas with an unknown primary.

P=N/A, N=5, Active, not recruiting, Memorial Sloan Kettering Cancer Center | Trial completion date: Jun 2026 --> Jun 2027 | Trial primary completion date: Jun 2026 --> Jun 2027

To fully realize the potential of miRNAs in thyroid cancer diagnostics, further research involving larger sample sizes and diverse tissue types is needed. Such efforts could pave the way for their integration into routine clinical practice and open new avenues for targeted therapies.

This case highlights the value of WBS and FDG-PET in detecting occult metastases in patients with persistent SrTg elevation. It also demonstrates that combining liver metastasectomy with tyrosine kinase inhibitor therapy (lenvatinib) may improve outcomes in selected patients with DTC and liver metastasis.