Thyroid Gland Follicular Carcinoma

P=N/A, N=1000, Not yet recruiting, Zhejiang Cancer Hospital; Zhejiang Cancer Hospital

P=N/A, N=228, Completed, Fujian Province Cancer Hospital; Fujian Province Cancer Hospital

RFA is a safe and effective treatment for patients with low-risk follicular neoplasm (SUVmax value < 5) in medium-term follow-up. For patients who are either ineligible for or prefer to avoid surgery, RFA presents a feasible alternative treatment option.

Unlike C-cell and ultimobranchial neoplasms, thyroid follicular carcinomas are rarely reported in cattle. The thyroid follicular-compact carcinoma described herein was associated with acute tympany.

FTC tumorigenesis is driven by distinct molecular pathways, with significant heterogeneity between pediatric and adult patients as well as primary and metastatic disease. These findings underscore the necessity of molecular profiling for patient stratification and provide a strong rationale for developing personalized treatment strategies to improve clinical outcomes.

Notably, we identified a protein interaction between TGM2 and HK1 that was significantly upregulated in the papillary thyroid carcinoma cell line TPC-1. ProteoAutoNet provides an improved framework for investigating protein-protein interactions and uncovering interactions.

This case represents the first reported collision tumor combining thyroid PEComa and FTC, with immunohistochemistry confirming the independent origins of both tumors. The findings expand our understanding of thyroid tumor varieties and highlight the crucial role of Ultrasound and histopathology in diagnosing and managing complex thyroid tumors, serving as a valuable reference for similar cases.

It underscores the importance of extensive sampling and a multidisciplinary approach for effective management. Given the lack of standardized treatment guidelines, personalised care and close follow-up are essential, with consideration of aggressive treatment based on risk assessment.

Analytical validation of the ultrasensitive immunoassay for FNA samples was obtained for 3 matrices; matrix features and sample storage at ‒20 °C do not affect the reliability of thyroglobulin measurements. Use of a protein matrix is recommended for possible presence of samples with low analyte values.

Combined measurement of serum CEA, Tg, CT, and TSH significantly enhances the diagnostic efficacy for TC, reducing both misdiagnosis and missed diagnosis rates, and provides a reliable basis for early clinical detection and intervention.

The present study discusses differences in tumor cell morphology and their diagnostic relevance in relation to previous reports, clinical history, histopathology and molecular pathology. The observations may contribute to improving diagnostic precision in cancer-to-cancer metastasis.

High PSMA expression in differentiated thyroid cancer was associated with shorter progression-free survival and may be considered a marker of aggressiveness. Such tumors could be candidates for targeted PSMA-radioligand therapy (e.g., 177 lutetium), particularly in radioiodine-negative/refractory cases, which are difficult to treat.