These findings suggest that appropriate dose reduction and genetic screening might be considered part of chemotherapy guidance to improve safety and effectiveness for patients with advanced gastric cancer undergoing hemodialysis.

EGCG-SeNPs confer superior protection against 5-FU-induced hepatorenal toxicity compared to EGCG or inorganic selenium alone. The potent protective effects of EGCG-SeNPs are mediated through coordinated antioxidant, anti-inflammatory, and anti-apoptotic mechanisms, primarily via activation of the Nrf2/HO-1 axis and suppression of NF-κB signaling.

For high-risk HCH patients, our findings regarding the tolerability of FOLFIRI-3 are strictly preliminary due to the small sample size and require further validation in larger, multi-institutional cohorts. Despite this limitation, this regimen serves as a valuable alternative for high-risk patients and provides superior survival benefits for single heterozygotes, likely due to optimized pharmacokinetics.

GV1001 markedly mitigated these 5-FU-induced mitochondrial defects. Taken together, GV1001 mitigates CIM by most likely preserving mitochondrial integrity and function, supporting its potential as a strategy to prevent cancer chemotherapy-associated mucosal injury in patients.

GDF15 promotes chemoresistance in CRC by promoting stem cell-like properties. These findings provide insights into therapeutic strategies for overcoming acquired chemoresistance and improving outcomes.

P2, N=17, Recruiting, West China Hospital | Not yet recruiting --> Recruiting | Trial completion date: Nov 2025 --> Jun 2026 | Trial primary completion date: Nov 2024 --> May 2026

P2, N=23, Active, not recruiting, Medical College of Wisconsin | Trial completion date: Mar 2026 --> Nov 2026

We investigated the effects of an olive fruit extract from Olea europaea L. (OE) combined with 5-fluorouracil (5-FU) or cisplatin (CIS) on human lung adenocarcinoma A549 cells. These findings indicate that OE potentiates the therapeutic effects of 5-FU and CIS by promoting alternative cell death pathways and modulating oxidative and ER stress responses. Our results support the potential use of Olea europaea as a safe and effective adjuvant in lung cancer treatment, providing a basis for further preclinical and clinical studies.

Following the recommendations of a further multidisciplinary team discussion, the patient continued on radiotherapy, a short course of endocrine therapy, and intensive therapy with capecitabine. During the 2-year follow-up period following the operation, the patient showed no signs of relapse or progression. The coordination of different disciplines is of paramount importance in ensuring the optimal treatment of locally advanced IBC patients, thereby facilitating a more favorable prognosis.

P1/2, N=45, Active, not recruiting, Guangzhou Medical University | Trial primary completion date: Jan 2026 --> Jul 2026

Only ER expression was associated with the overall survival time when other confounding factors such as smoking status and treatment type were considered. A smoking history was associated with shorter survival, while eribulin was associated with survival prolongation.

At diagnosis, the probability of resection after induction (m)FOLFIRINOX for localized PDAC ranged from 7% to 82%, depending on anatomical stage, CA19-9 level, performance status, and tumor size at baseline. This prediction model may help communicating realistic expectations for the probability of resection.