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    BIOMARKER:

    THY1 overexpression

    i
    Other names: THY1, Thy-1 membrane glycoprotein, CDw90, Thy-1 antigen, CD90, Thy-1 cell surface antigen
    Entrez ID:
    7070
    3ms
    High Expression of THY1 in Intestinal Gastric Cancer as a Key Factor in Tumor Biology: A Poor Prognosis-Independent Marker Related to the Epithelial-Mesenchymal Transition Profile. (PubMed, Genes (Basel))
    This signature showed EMT and remodeling of the tumor tissue composition potentially related to the biology of IGC. Altogether, our results indicate that THY1 IGC tumors are a particular subset of tumors with a specific molecular and prognosis profile.
    Journal
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    THY1 (Thy-1 membrane glycoprotein)
    |
    THY1 overexpression
    over1year
    Correlation of Clonal Hematopoiesis in Vexas Syndrome with Immunophenotype Alterations in CD34+ HSPCs (Hematopoietic Stem Progenitors Cells): Multiparametric Flow Cytometry Heterogeneity in CD34+CD38- Stem Cells Fraction and Upregulation of CD90 Thy-1 By Unsupervised Strategy Using PCA, Tsnee and Flowsom (ASH 2022)
    This is the first large immunophenotypic characterisation by flow of clonal haematopoiesis in UBA1 mutated patients. Our results showed that VEXAS syndrome is characterized by overexpression of CD90 Thy-1 primitive Stem cell markers in CD34+ HSPCs and in most immature CD34+CD38- fraction. Altogether, we can hypothesize that such phenotype might represent specific disease hallmark involved in physiopathology of niche deregulation, which should be confirmed in a larger cohort of patients in a future multicentric clinical trials to improve biological diagnosis and comprehension of kinetics of clonal haematopoiesis in VEXAS patients.
    IO biomarker
    |
    KIT (KIT proto-oncogene, receptor tyrosine kinase) • CD19 (CD19 Molecule) • CD38 (CD38 Molecule) • CD123 (Interleukin 3 Receptor Subunit Alpha) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • CD33 (CD33 Molecule) • CD34 (CD34 molecule) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • NCAM1 (Neural cell adhesion molecule 1) • CD7 (CD7 Molecule) • THY1 (Thy-1 membrane glycoprotein) • ANPEP (Alanyl Aminopeptidase, Membrane)
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    CD38 expression • THY1 overexpression