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    GENE:

    THBS4 (Thrombospondin 4)

    i
    Other names: THBS4, Thrombospondin 4, Thrombospondin-4, TSP4, TSP-4
    Associations

    News

    Trials
    5ms
    Thrombospondin-4 from Cancer-associated Fibroblasts Downregulates ERBB2 Expression in Gastric Cancer Cells. (PubMed, Carcinogenesis)
    The effects of Herceptin or gabapentin, a THBS4 receptor inhibitor, on subcutaneous tumors were examined in nude mice...In vivo, CAFs suppress HER2 expression of subcutaneous GC tumors and induce Herceptin resistance...THBS4 from CAFs downregulated HER2 (ERBB2) expression in GC cells. Thus, THBS4 receptor inhibitors may be useful in preventing the acquisition of resistance to anti-HER2 therapy.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2) • THBS4 (Thrombospondin 4)
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    HER-2 positive • HER-2 expression
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    Herceptin (trastuzumab) • Herceptin Hylecta (trastuzumab/hyaluronidase-oysk)
    10ms
    Transcriptome sequencing revealed that lymph node metastasis of papillary thyroid microcarcinoma is associated with high THBS4 expression and PDGFRA+ cancer-associated fibroblasts. (PubMed, Front Oncol)
    This study's findings indicate that THBS4 could be a potential biomarker for predicting the risk of lymph node metastasis in papillary thyroid microcarcinoma, thus potentially guiding more personalized surgical interventions. Further validation in larger patient cohorts and the interactions between THBS4 and CAFs are necessary.
    Journal
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    PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • THBS4 (Thrombospondin 4)
    over1year
    Histone Methyltransferase MLL4 Protects Against Pressure Overload-Induced Heart Failure via A THBS4-mediated Protection in ER Stress. (PubMed, Pharmacol Res)
    Mechanistically, MLL4 acts as a transcriptional activator of Thbs4 through mono-methylation of H3K4 and further regulates THBS4-dependent ER stress response, ultimately plays a role in HF. Our study indicates that pharmacologically targeting MLL4 and ER stress might be a valid therapeutic approach to protect against cardiac hypertrophy and HF.
    Journal • Epigenetic controller
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    KMT2D (Lysine Methyltransferase 2D) • THBS4 (Thrombospondin 4)
    over2years
    B4GALNT1 promotes hepatocellular carcinoma stemness and progression via integrin α2β1-mediated FAK and AKT activation. (PubMed, JHEP Rep)
    Here, we reveal that B4GALNT1 has a crucial role in HCC stemness and progression by activating the integrin α2β1/FAK/PI3K/AKT axis, providing a potential target for HCC therapy. In addition, we find Ophiopogonin D as a potential therapeutic drug for patients with HCC.
    Journal
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    B4GALNT1 (Beta-1,4-N-Acetyl-Galactosaminyltransferase 1) • ITGB1 (Integrin Subunit Beta 1) • THBS4 (Thrombospondin 4)
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    B4GALNT1 expression
    over2years
    Primary testicular lymphoma demonstrates overexpression of the Wilms tumor 1 gene and different mRNA and miRNA expression profiles compared to nodal diffuse large B-cell lymphoma. (PubMed, Hematol Oncol)
    This research revealed higher WT1 expression in PTL relative to nodal DLBCL, suggesting that a specific miRNA subset may target WT1 expression and impact the PI3k/Akt pathway in PTL. Further investigation is needed to explore WT1's biological role in PTL and its potential as a therapeutic target.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • CD79B (CD79b Molecule) • WT1 (WT1 Transcription Factor) • GAS1 (Growth Arrest Specific 1) • LAMC2 (Laminin subunit gamma 2) • MIR199B (MicroRNA 199b) • MIR132 (MicroRNA 132) • MIR16 (MicroRNA 16) • MIR199A (MicroRNA 199a) • MIR27B (MicroRNA 27b) • MIR361 (MicroRNA 361) • MIR128 (MicroRNA 128) • MMP7 (Matrix metallopeptidase 7) • THBS4 (Thrombospondin 4)
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    MYD88 mutation • CD79B mutation • WT1 overexpression • GAS1 expression