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    BIOMARKER:

    THBS2-L

    i
    Other names: THBS2, Thrombospondin 2, TSP2
    Entrez ID:
    7058
    1year
    The Efficacy of FOLFIRI Plus Ramucirumab in Recurrent Colorectal Cancer Refractory to Adjuvant Chemotherapy with Oxaliplatin/Fluoropyrimidine-Including Biomarker Analyses. (PubMed, Cancers (Basel))
    Our data suggested that FOLFIRI plus ramucirumab was effective and tolerable for CRC refractory to fluoropyrimidine and oxaliplatin without anti-angiogenesis. Serum VEGF-D levels may not be predictive but TSP-2 may be a potential prognostic biomarker for ramucirumab's efficacy.
    Journal
    |
    RAS (Rat Sarcoma Virus) • VEGFD (Vascular Endothelial Growth Factor D)
    |
    RAS mutation • THBS2-L
    |
    Avastin (bevacizumab) • 5-fluorouracil • Cyramza (ramucirumab) • oxaliplatin • irinotecan • leucovorin calcium
    over2years
    Systematic analysis of integrated bioinformatics to identify upregulated THBS2 expression in colorectal cancer cells inhibiting tumour immunity through the HIF1A/Lactic Acid/GPR132 pathway. (PubMed, Cancer Cell Int)
    THBS2 expression is associated with PFI, immune cell infiltration, immune regulation, cell death, cell migration, epithelial-mesenchymal transition, angiogenesis and genomic variations in COAD. THBS2 may serve as a biomarker for immunotherapy in COAD. Upregulated THBS2 expression in CRC cells inhibits anti-tumour immunity through the HIF1A/lactic acid/GPR132 pathway.
    Journal • IO biomarker
    |
    HIF1A (Hypoxia inducible factor 1, alpha subunit) • THBS2 (Thrombospondin 2)
    |
    HIF1A expression • THBS2-L
    3years
    Thrombospondin-2 as a Predictive Biomarker for Hepatocellular Carcinoma after Hepatitis C Virus Elimination by Direct-Acting Antiviral. (PubMed, Cancers (Basel))
    Serum TSP-2 levels are a predictive biomarker of HCC occurrence in CHC patients after HCV elimination by DAA treatment. The AFT score using TSP-2, AFP, and the FIB-4 index may identify those who require HCC surveillance.
    Journal
    |
    AFP (Alpha-fetoprotein) • THBS2 (Thrombospondin 2)
    |
    THBS2-L