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    GENE:

    TGIF2 (TGFB Induced Factor Homeobox 2)

    i
    Other names: TGIF2, TGFB Induced Factor Homeobox 2, TGFB-Induced Factor 2 (TALE Family Homeobox), Homeobox Protein TGIF2, Transcription Growth Factor-Beta-Induced Factor 2, TGF(Beta)-Induced Transcription Factor 2, TGF-Beta-Induced Transcription Factor 2, TGFB-Induced Factor Homeobox 2, 5’-TG-3' Interacting Factor 2, 5'-TG-3'-Interacting Factor 2, TGFB-Induced Factor 2
    Associations

    News

    Trials
    4d
    TGIF2-mediated HMGB3 overexpression promotes esophageal squamous cell carcinoma proliferation and metastasis through TLR3/TGF-β signaling. (PubMed, Genes Dis)
    The functional role of HMGB3 in ESCC proliferation and metastasis was illustrated in our research. Targeting the TGIF2/HMGB3/TLR3/TGF-β axis has the potential to serve as a promising therapeutic approach.
    Journal • IO biomarker
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    TGFB1 (Transforming Growth Factor Beta 1) • TLR3 (Toll Like Receptor 3) • TGIF2 (TGFB Induced Factor Homeobox 2)
    4ms
    Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations. (PubMed, Mol Med Rep)
    Additionally, molecular docking and molecular dynamics simulations were employed to explore the molecular mechanisms underlying the antitumor activity of compound 1. The results suggest that compound 1 exerts its anticancer effects in cervical cancer by regulating the expression of genes TGIF2, ID1 and BMP2.
    Journal
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    TGIF2 (TGFB Induced Factor Homeobox 2) • BMP2 (Bone Morphogenetic Protein 2)
    8ms
    Expression of Concern. (PubMed, Eur Rev Med Pharmacol Sci)
    Downregulated long non-coding RNA TRPM2-AS inhibits cisplatin resistance of non-small cell lung cancer cells via activation of p53- p66shc pathway...PMID: 33577026. The Publisher apologizes for any inconvenience this may cause.
    Journal
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    IGF2 (Insulin-like growth factor 2) • MIR200B (MicroRNA 200b) • NEAT1 (Nuclear Paraspeckle Assembly Transcript 1) • FUS (FUS RNA Binding Protein) • TIMP2 (TIMP Metallopeptidase Inhibitor 2) • AFAP1-AS1 (AFAP1 Antisense RNA 1) • FOXO3 (Forkhead box O3) • PCNA (Proliferating cell nuclear antigen) • GAS5 (Growth Arrest Specific 5) • SMAD7 (SMAD Family Member 7) • DSCAM (DS Cell Adhesion Molecule) • HOXA-AS2 (HOXA Cluster Antisense RNA 2) • MIR29A (MicroRNA 29a) • MIR483 (MicroRNA 483) • MMP7 (Matrix metallopeptidase 7) • RBM24 (RNA Binding Motif Protein 24) • SNHG7 (Small Nucleolar RNA Host Gene 7) • TGFBR1 (Transforming Growth Factor Beta Receptor 1) • TGIF2 (TGFB Induced Factor Homeobox 2) • WTAP (WT1 Associated Protein) • XIST (X Inactive Specific Transcript) • MAGI2-AS3 (MAGI2 Antisense RNA 3)
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    cisplatin
    11ms
    FBLN2 inhibits gastric cancer proliferation and metastasis via the TGFβ/TGIF2 pathway. (PubMed, Pathol Res Pract)
    In addition, in terms of the clinical data, we revealed a correlation between FBLN2 and TGIF2 and patient prognosis. In summary, our study revealed that FBLN2 suppressed GC proliferation, migration and invasion by downregulating the TGFβ/TGIF2 axis, suggesting that FBLN2 is a promising target for GC treatment.
    Journal
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    TGFB1 (Transforming Growth Factor Beta 1) • TGIF2 (TGFB Induced Factor Homeobox 2)
    1year
    Smad2 Cooperating with TGIF2 Contributes to EMT and Cancer Stem Cells Properties in Pancreatic Cancer via Co-Targeting SOX2. (PubMed, Int J Biol Sci)
    Moreover, the interaction of TGIF2 and SOX2 with EGFR inhibitors promoted subcutaneous tumors and liver metastasis in vivo. Thus, the TGIF2/SOX2 axis contributes to CSC, EMT, and chemoresistance, providing a promising target for PC therapy.
    Journal
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    CDH1 (Cadherin 1) • SOX2 • SNAI2 (Snail Family Transcriptional Repressor 2) • SMAD2 (SMAD Family Member 2) • TGIF2 (TGFB Induced Factor Homeobox 2)
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    CDH1 expression
    over1year
    miRNA-driven sensitization of breast cancer cells to Doxorubicin treatment following exposure to low dose of Zinc Oxide nanoparticles. (PubMed, Saudi Pharm J)
    This study insinuates the importance of miRNAs in regulating the responsiveness of cancer cells to chemotherapy. Our findings further indicate that being exposed to environmental ENMs, even at levels below toxicity, might still modulate cancer cells' response to chemotherapy, which highlights the need to reestablish endpoints of ENM exposure and toxicity in cancer patients receiving chemotherapeutics.
    Journal
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    SMAD4 (SMAD family member 4) • BCL2L11 (BCL2 Like 11) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • CDKN1B (Cyclin dependent kinase inhibitor 1B) • SMAD2 (SMAD Family Member 2) • TGIF2 (TGFB Induced Factor Homeobox 2) • YWHAG (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma)
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    doxorubicin hydrochloride
    almost2years
    circVAPA-rich small extracellular vesicles derived from gastric cancer promote neural invasion by inhibiting SLIT2 expression in neuronal cells. (PubMed, Cancer Lett)
    Mechanistically, sEV-circVAPA decreases SLIT2 transcription by miR-548p/TGIF2 and inhibits SLIT2 translation via binding to eIF4G1, thereby downregulates SLIT2 expression in neuronal cells and finally induces GC-NI. Together, this work identifies the preferential absorption mechanism of GC-derived sEVs by neuronal cells and demonstrates a previously undefined role of GC-derived sEV-circRNA in GC-NI, which provides new insight into sEV-circRNA based diagnostic and therapeutic strategies for NI-positive GC patients.
    Journal
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    SLIT2 (Slit Guidance Ligand 2) • EIF4G1 (Eukaryotic translation initiation factor 4 gamma, 1) • TGIF2 (TGFB Induced Factor Homeobox 2)
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    SLIT2 expression
    almost2years
    TGIF2 is a potential biomarker for diagnosis and prognosis of glioma. (PubMed, Front Immunol)
    Additionally, in vitro experiments revealed that knockdown and knockout of TGIF2 inhibited glioma cell invasion, migration and suppressed the epithelial-mesenchymal transition (EMT) phenotype. TGIF2 emerges as a potential biomarker for glioma, possibly linked to tumor immune infiltration and EMT.
    Journal
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    TGIF2 (TGFB Induced Factor Homeobox 2)
    2years
    Comprehensive analysis reveals TSPEAR as a prognostic biomarker in colorectal cancer. (PubMed, J Cancer)
    Additionally, TSPEAR plays a significant role in tumor immunity and the biological behavior of CRC cells. Thus, TSPEAR may become a promising prognostic biomarker and therapeutic target for CRC patients.
    Journal • Tumor mutational burden
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    TMB (Tumor Mutational Burden) • TGIF2 (TGFB Induced Factor Homeobox 2)
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    TMB-H
    2years
    Jagged1 intracellular domain/SMAD3 complex transcriptionally regulates TWIST1 to drive glioma invasion. (PubMed, Cell Death Dis)
    Moreover, JICD1-TWIST1-MMP2 and MMP9 axes were significantly correlated with clinical outcome of glioblastoma patients. Collectively, we identified the JICD1/SMAD3-TWIST1 axis as a novel inducer of invasive phenotypes in cancer cells.
    Journal
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    MMP2 (Matrix metallopeptidase 2) • TGFB1 (Transforming Growth Factor Beta 1) • MMP9 (Matrix metallopeptidase 9) • TWIST1 (Twist Family BHLH Transcription Factor 1) • JAG1 (Jagged Canonical Notch Ligand 1) • DDX17 (DEAD-Box Helicase 17) • SMAD3 (SMAD Family Member 3) • TGIF2 (TGFB Induced Factor Homeobox 2)
    over2years
    TMEM147 is a novel biomarker for diagnosis and prognosis of hepatocellular carcinoma. (PubMed, Genet Mol Biol)
    Further analysis revealed that TMEM147 mainly impacted the ribosome pathway, and CTCF, MLLT1, TGIF2, ZNF146, and ZNF580 were predicted to be the upstream transcription factors for TMEM147 in HCC. These results suggest that TMEM147 serves as a promising biomarker for diagnosis and prognosis and may potentially become a therapeutic target for HCC.
    Journal
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    TGIF2 (TGFB Induced Factor Homeobox 2)
    almost3years
    Hsa_circ_0063329 inhibits prostate cancer growth and metastasis by modulating the miR-605-5p/tgif2 axis. (PubMed, Cell Cycle)
    Mechanistically, bioinformatics analysis, RNA pulldown, RNA-seq and dual-luciferase reporter assays demonstrated that hsa_circ_0063329 exerts its effect by sponging miR-605-5p to derepress TG-interacting factor 2 (TGIF2) and inactivate the TGF-β pathway. In conclusion, hsa_circ_0063329 inhibits the proliferation and metastasis of PCa via modulation of the miR-605-5p/TGIF2 axis, and targeting hsa_circ_0063329 may provide a promising treatment strategy for aggressive PCa.
    Journal
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    TGFB1 (Transforming Growth Factor Beta 1) • TGIF2 (TGFB Induced Factor Homeobox 2)